(Dimethoxymethyl)-trimethoxysilan | 22859-33-2

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (Dimethoxymethyl)-trimethoxysilan
• 英文别名: Dimethoxymethyl(trimethoxy)silane；dimethoxymethyl(trimethoxy)silane
• CAS: 22859-33-2
• 化学式: C₆H₁₆O₅Si
• 分子量: 196.276
• InChiKey: JTOUCZIOCGOWIX-UHFFFAOYSA-N

物化性质

• 沸点：
  124.4±30.0 °C(Predicted)
• 密度：
  1.003±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.02
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  莰烯 、 (Dimethoxymethyl)-trimethoxysilan 生成
  参考文献：
  名称：

  Gream,G.E.; Pincombe,C.F., Australian Journal of Chemistry, 1974, vol. 27, p. 543 - 565

  摘要：

  DOI：
• 作为产物：
  描述：

  甲醇 、 (bromo(methoxy)methyl)trimethoxysilane 在 三乙胺 作用下， 以 乙醚 为溶剂， 反应 2.0h， 以60%的产率得到(Dimethoxymethyl)-trimethoxysilan
  参考文献：
  名称：

  Synthesis and Olfactory Characterization of Sila-Methyl Pamplemousse and Related Odorants with a 2,2,5-Trimethyl-2-silahex-4-ene Skeleton

  摘要：

  The synthetic grapefruit odorant methyl pamplemousse (1a) has lately become an important trend odorant, and the related 2,2,5-trimethylhex-4-enes 2a-4a also possess interesting olfactory properties of fresh hesperidic and fruity-agrestic character. On the basis of the carbon/silicon switch strategy, the silicon-containing analogues silamethyl pamplemousse (1b) and 2b-4b were synthesized and studied for their olfactory properties (olfactory evaluation of the C/Si pairs 1a/1b-4a/4b). Si la substitution (C/Si exchange) was demonstrated to affect the olfactory properties substantially. The C/Si analogues la and 1b were found to be genuine grapefruit odorants, with the silicon compound 1b showing additional agrestic facets. As a proof of principle, it Was demonstrated that C/Si analogues can display a different mechanism and rate of degradation (degradation studies with la and 1b under acidic conditions).

  DOI：

  10.1021/om401181h

文献信息

• Thermolysis of methoxymethylsilanes. I. Formation of methoxycarbene
  作者：William H. Atwell、Donald R. Weyenberg、John G. Ulhmann

  DOI：10.1021/ja01036a027

  日期：1969.4
• Gream,G.E.; Pincombe,C.F., Australian Journal of Chemistry, 1974, vol. 27, p. 543 - 565
  作者：Gream,G.E.、Pincombe,C.F.

  DOI：——

  日期：——
• Synthesis and Olfactory Characterization of Sila-Methyl Pamplemousse and Related Odorants with a 2,2,5-Trimethyl-2-silahex-4-ene Skeleton
  作者：Julian Friedrich、Steffen Dörrich、André Berkefeld、Philip Kraft、Reinhold Tacke

  DOI：10.1021/om401181h

  日期：2014.2.10

  The synthetic grapefruit odorant methyl pamplemousse (1a) has lately become an important trend odorant, and the related 2,2,5-trimethylhex-4-enes 2a-4a also possess interesting olfactory properties of fresh hesperidic and fruity-agrestic character. On the basis of the carbon/silicon switch strategy, the silicon-containing analogues silamethyl pamplemousse (1b) and 2b-4b were synthesized and studied for their olfactory properties (olfactory evaluation of the C/Si pairs 1a/1b-4a/4b). Si la substitution (C/Si exchange) was demonstrated to affect the olfactory properties substantially. The C/Si analogues la and 1b were found to be genuine grapefruit odorants, with the silicon compound 1b showing additional agrestic facets. As a proof of principle, it Was demonstrated that C/Si analogues can display a different mechanism and rate of degradation (degradation studies with la and 1b under acidic conditions).