trimethyl[3-(triisopropylsilyloxy)-1-propynyl]silane | 193007-93-1

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: trimethyl[3-(triisopropylsilyloxy)-1-propynyl]silane
• 英文别名: 1-trimethylsilyl-3-triisopropylsilyloxypropyne；Trimethyl(3-{[tri(propan-2-yl)silyl]oxy}prop-1-yn-1-yl)silane；trimethyl-[3-tri(propan-2-yl)silyloxyprop-1-ynyl]silane
• CAS: 193007-93-1
• 化学式: C₁₅H₃₂OSi₂
• 分子量: 284.589
• InChiKey: YONLFFWCJOOEJO-UHFFFAOYSA-N

物化性质

• 沸点：
  273.7±23.0 °C(Predicted)
• 密度：
  0.840±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.06
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  二甲氧基苯甲醇 、 trimethyl[3-(triisopropylsilyloxy)-1-propynyl]silane 在 copper(ll) bromide 作用下， 以 乙腈 为溶剂， 反应 1.5h， 以89%的产率得到3-[Bis(4-methoxyphenyl)methoxy]prop-1-ynyl-trimethylsilane
  参考文献：
  名称：

  Copper(II) bromide as efficient catalyst for silyl- to bisarylmethyl ethers interconversion (transprotection)

  摘要：

  Primary and secondary silylated alcohols are easily converted to bis(methoxyphenyl)methyl (BMPM) ethers in good yields using CuBr2 as catalyst in acetonitrile at room temperature. Various other protecting groups are compatible with this mild and convenient process. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.08.148

文献信息

• 17-SIDE CHAIN ALKYNL-AND 20-OXOPREGNA-DERIVATIVES OF VITAMIN D, METHODS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS THEREOF
  申请人：——

  公开号：US20020010163A1

  公开（公告）日：2002-01-24

  1-Hydroxy pregnacalciferol derivatives of formula (I) and their corresponding 5,6-trans isomers wherein R 1 is hydroxyl or lower alkoxy and R 2 is optionally hydroxylated or lower alkoxylated lower alkynyl or R 1 is C(R A ) (R B )CH 3 where R A is optionally hydroxylated or lower alkoxylated lower alkynyl and R B is hydroxyl or lower alkoxy or R A and R B together represent oxo and R 2 is hydrogen, hydroxyl or lower alkoxy, and R 3 and R 4 represent hydrogen atoms, exhibit anti-progesterone activity and may be useful as antineoplastic, antifertility, antiproliferative, immunosuppressive and/or antiinflammatory agents.

  公式（I）中的1-羟基孕酮类衍生物及其相应的5,6-顺式异构体，其中R1是羟基或较低的烷氧基，R2是可选择地羟化或较低烷氧化的较低炔基，或者R1是C（RA）（RB）CH3，其中RA是可选择地羟化或较低烷氧化的较低炔基，RB是羟基或较低的烷氧基，或者RA和RB一起代表羰基，R2是氢、羟基或较低的烷氧基，R3和R4代表氢原子，表现出抗孕激素活性，可能作为抗肿瘤、抗生育、抗增殖、免疫抑制和/或抗炎药物有用。
• Highly Enantioselective Synthesis of Chiral 3-Substituted Indolines by Catalytic Asymmetric Hydrogenation of Indoles
  作者：Ryoichi Kuwano、Kohei Kaneda、Takashi Ito、Koji Sato、Takashi Kurokawa、Yoshihiko Ito

  DOI：10.1021/ol049317k

  日期：2004.6.1

  text] N-Tosyl 3-substituted indoles were hydrogenated with high enantioselectivities (95-98% ee) by use of a trans-chelating chiral bisphosphine, (S,S)-(R,R)-PhTRAP ligand. The chiral catalyst, which was generated in situ from [Rh(nbd)(2)]SbF(6), PhTRAP, and Cs(2)CO(3), is useful for enantioselectively synthesizing a range of diverse optically active indolines possessing a chiral carbon at the 3-position

  [反应：见正文]通过使用反式螯合手性双膦（S，S）-（R，R）-PhTRAP配体，以高对映选择性（95-98％ee）将N-甲苯磺酰基3取代的吲哚氢化。由[Rh（nbd）（2）] SbF（6），PhTRAP和Cs（2）CO（3）原位生成的手性催化剂可用于对映选择性合成一系列具有在3位的手性碳。
• US6372926
  申请人：——

  公开号：——

  公开（公告）日：——
• Copper(II) bromide as efficient catalyst for silyl- to bisarylmethyl ethers interconversion (transprotection)
  作者：Simon Specklin、Florian Gallier、Rofia Mezaache、Hassina Harkat、Yénimégué Albert Dembelé、Jean-Marc Weibel、Aurélien Blanc、Patrick Pale

  DOI：10.1016/j.tetlet.2011.08.148

  日期：2011.11

  Primary and secondary silylated alcohols are easily converted to bis(methoxyphenyl)methyl (BMPM) ethers in good yields using CuBr2 as catalyst in acetonitrile at room temperature. Various other protecting groups are compatible with this mild and convenient process. (C) 2011 Elsevier Ltd. All rights reserved.