aminobis(methylenediethyl phosphite) | 2423-98-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: aminobis(methylenediethyl phosphite)
• 英文别名: imidodiphosphate tetraethyl ester；tetraethyl imidodiphosphate；Tetraethyl-imidodiphosphat；μ-imido-diphosphoric acid tetraethyl ester；bis(diethyl-phosphonato)-amine；Diethyl-(O,O-diethyl-phosphonoamino)-phosphat；[(diethoxyphosphorylamino)-ethoxyphosphoryl]oxyethane
• CAS: 2423-98-5
• 化学式: C₈H₂₁NO₆P₂
• 分子量: 289.205
• InChiKey: UBZAYQFNNNKKKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  17
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  83.1
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  重氮乙烷 、 aminobis(methylenediethyl phosphite) 以 乙醚 为溶剂， 生成 Triethoxyphosphazen-N-phosphoryldiethylester
  参考文献：
  名称：

  On imides op the phosphorus acids

  摘要：

  DOI：

  10.1007/bf00909162
• 作为产物：
  描述：

  Triethoxyphosphazen-N-phosphoryldiethylester 在 盐酸 作用下， 以 乙醚 为溶剂， 反应 24.0h， 以76.2%的产率得到aminobis(methylenediethyl phosphite)
  参考文献：
  名称：

  亚氨基二磷酸乙酯和甲硅烷基酯：通过施陶丁格反应获得磷-氮-磷键的替代途径

  摘要：

  AbstractWe present herein an alternative synthesis route to obtain tetraethyl imidodiphosphate (EtO)2P(O)NH(O)P(OEt)2 (3) and its silylester derivative tetrakis(trimethylsilyl) imidodiphosphate (Me3SiO)2P(O)NH(O)P(OSiMe3)2 (4) involving a phosphorazidate intermediate (1) and the Staudinger reaction. Compared to previous methods, this synthesis route is simpler, more atom efficient, and energetically inexpensive. Moreover, the final compounds are obtained with larger yield and higher purity.

  DOI：

  10.1002/hc.21413

文献信息

• LUMINESCENT PROBES FOR BIOLOGICAL LABELING AND IMAGING, METHOD FOR PREPARING SAME
  申请人：UNIVERSITE DE STRASBOURG

  公开号：US20140228553A1

  公开（公告）日：2014-08-14

  The present invention relates to organic compounds that are usable as ligands for preparing complexes of lanthanides or of certain transition metals which are water-soluble, to a method for preparing same, and also to the use thereof as a fluorescent probe.

  本发明涉及作为配体用于制备镧系元素或某些过渡金属的水溶性配合物的有机化合物，涉及制备方法以及将其用作荧光探针的用途。
• Gilyarov, V. A.; Matrosov, E. I.; Bel'skii, F. I., Journal of general chemistry of the USSR, 1980, vol. 50, # 1, p. 35 - 38
  作者：Gilyarov, V. A.、Matrosov, E. I.、Bel'skii, F. I.、Kabachnik, M. I.

  DOI：——

  日期：——
• Koehler, Helmut; Jaeger, Lothar; Gebel, Wolfgang, Zeitschrift fur Chemie, 1989, vol. 29, # 4, p. 145 - 146
  作者：Koehler, Helmut、Jaeger, Lothar、Gebel, Wolfgang

  DOI：——

  日期：——
• KOHLER, HELMUT;JUGER, LOTHAR;GEBEL, WOLFGANG, Z. CHEM., 29,(1989) N, C. 145-146
  作者：KOHLER, HELMUT、JUGER, LOTHAR、GEBEL, WOLFGANG

  DOI：——

  日期：——
• Ethyl ester and silyl ester of imidodiphosphate: An alternative route to access phosphorus-nitrogen-phosphorus bonds via Staudinger reaction
  作者：Jia En Low、Joëlle Levalois-Grützmacher

  DOI：10.1002/hc.21413

  日期：2018.1

  AbstractWe present herein an alternative synthesis route to obtain tetraethyl imidodiphosphate (EtO)2P(O)NH(O)P(OEt)2 (3) and its silylester derivative tetrakis(trimethylsilyl) imidodiphosphate (Me3SiO)2P(O)NH(O)P(OSiMe3)2 (4) involving a phosphorazidate intermediate (1) and the Staudinger reaction. Compared to previous methods, this synthesis route is simpler, more atom efficient, and energetically inexpensive. Moreover, the final compounds are obtained with larger yield and higher purity.