申请人:MITSUI CHEMICALS, INC.
公开号:EP0257102A1
公开(公告)日:1988-03-02
A medicinal composition comprising a pyrimidine compound represented by following general formula (I), wherein R' represents a hydrogen atom, an acyl group having 2 to 4 carbon atoms, an alkoxycarbonyl group having 2 to 5 carbon atoms, an alkoxycarbonylmethyl group having 3 to 5 carbon atoms a benzyl group, a 3,4-dimethoxybenzoyl group or a 3,4-methylenedioxybenzyl group; R2 represents a hydrogen atom, an amino group, a monoalkylamino group having 1 to 4 carbon atoms, an alkoxy group having 1 to 5 carbon atoms or an alkoxycarbonyl group having 2 to 4 carbon atoms; R3 represents a hydrogen atom, an alkoxycarbonyl group having 2 to 4 carbon atoms, a dialkylaminocarbonyl group having 1 to 9 carbon atoms in each alkyl moiety, an alkoxy group having 1 to 5 carbon atoms or a hydroxyethyl group, or R2 and R3 may be taken together to form a 4- to 7-membered carbocyclic or heterocyclic ring containing N, 0 or S as a hetero atom together with the carbon atom to which R2 and R3 ar bound: and R4 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or an alkylthio group having 1 to 4 carbon atoms, or a pharmaceutically acceptable salt thereof is disclosed. These active compounds show activities of promoting growth of neural cells, forming neurites and restoring kinetic functions, thus being useful as agents for treating diseases of peripheral and central nerves.
一种药物组合物,包含由以下通式(I)代表的
嘧啶化合物,其中 R'代表
氢原子、具有 2 至 4 个
碳原子的酰基、具有 2 至 5 个
碳原子的烷
氧羰基、具有 3 至 5 个
碳原子的烷
氧羰
甲基、
苄基、3,4-二
甲氧基苯甲酰基或 3,4-亚甲二
氧基
苄基;R2 代表
氢原子、
氨基、具有 1 至 4 个
碳原子的单烷基
氨基、具有 1 至 5 个
碳原子的烷
氧基或具有 2 至 4 个
碳原子的烷
氧羰基;R3 代表
氢原子、具有 2 至 4 个
碳原子的烷
氧羰基、每个烷基中具有 1 至 9 个
碳原子的二烷基
氨基羰基、具有 1 至 5 个
碳原子的烷
氧基或羟乙基,或 R2 和 R3 可结合在一起形成 4 至 7 元
碳环或杂环,其中 N、0 或 S 作为杂原子与 R2 和 R3 所结合的
碳原子一起:和 R4 代表
氢原子、1 至 4 个
碳原子的烷基或 1 至 4 个
碳原子的烷
硫基,或其药学上可接受的盐。这些活性化合物具有促进神经细胞生长、形成神经元和恢复动力功能的活性,因此可作为治疗周围神经和中枢神经疾病的药物。