Tributyl-phosphin-dibromid | 4092-19-7

• 分子结构分类: 有机化合物 - 有机磷化合物
• 英文名称: Tributyl-phosphin-dibromid
• 英文别名: Dibromo(tributyl)-lambda5-phosphane；dibromo(tributyl)-λ5-phosphane
• CAS: 4092-19-7
• 化学式: C₁₂H₂₇Br₂P
• 分子量: 362.128
• InChiKey: HTGOWFMBQFBMPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  15
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  锰 、 Tributyl-phosphin-dibromid 以 乙醚 为溶剂， 以>99的产率得到
  参考文献：
  名称：

  The reaction of bromo- and iodo-phosphoranes with unactivated coarse grain manganese metal powder to yield [MnI₂(phosphine)₂] and [{MnX₂(phosphine)}_n](X = Br or I) by insertion of Mn into the P–X bond. The crystal structure of [MnI₂(PPh₃)₂]

  摘要：

  The novel reaction of crude manganese metal powder with dibromo- and diiodo-phosphoranes, R3PX2, has been studied. Reaction of the phosphoranes R3PI2 (R = phenyl or substituted aryl) with manganese allows insertion of the metal into P-X bonds and gives the monomeric tetrahedral complexes [MnI2(PR3)2] and MnI2. However, reaction of R3PX2 (R3 = mixed aryl/alkyl, trialkyl; X = Br or I) with manganese, whilst once again proceeding via insertion into P-X bonds, now leads to the quantitative isolation of the polymeric complexes [{MnX2(PR3)}n], thus illustrating the subtle nature of these reactions. Examples of both types of complex have been crystallographically characterised and represent rare examples of such. There is some evidence that where R3 = Ph2Me an equilibrium exists and both types of complex, [MnI2(PPh2Me)2] and [{MnI2(PPh2Me)}n] can be detected from the same reaction.

  DOI：

  10.1039/dt9930000371
• 作为产物：
  描述：

  (1-Bromo-1,3,3,4,4,5,5,5-octafluoro-2-oxo-pentyl)-tributyl-phosphonium; bromide 在 溴 作用下， 以79%的产率得到1,1-dibromoperfluoro-2-pentanone
  参考文献：
  名称：

  α，α-二卤代氟甲基全氟烷基酮的区域特异性制备

  摘要：

  -磷鎓盐与-酰氯的酰化以高收率得到相应的-全氟甜菜碱。随后的氯化或溴化区域特异性地产生α，α-二卤代氟甲基全氟烷基酮。

  DOI：

  10.1016/s0040-4039(00)83859-9
• 作为试剂：
  描述：

  [1,1-2H2]新戊醇 在 Tributyl-phosphin-dibromid 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 1-溴-2,2-二甲基丙烷-1,1-D2
  参考文献：
  名称：

  Multiple metal-carbon bonds. 8. Preparation, characterization, and mechanism of formation of the tantalum and niobium neopentylidene complexes, M(CH2CMe3)3(CHCMe3)

  摘要：

  DOI：

  10.1021/ja00479a019

文献信息

• [EN] AN IMPROVED PROCESS FOR THE PREPARATION OF DARIFENACIN HYDROBROMIDE<br/>[FR] PROCÉDÉ PERFECTIONNÉ POUR LA PRÉPARATION DE BROMHYDRATE DE DARIFÉNACINE
  申请人：AUROBINDO PHARMA LTD

  公开号：WO2011070419A1

  公开（公告）日：2011-06-16

  The present invention relates to an improved process for the preparation of Darifenacin hydrobromide of Formula (I). (i) condensing 3-(S)-(-)-1l-carbamoyl-1,1-diphenylmethyl)pyrrolidine (III), or its salt, with a compound of Formula XIII in the presence of a. base in a solvent, wherein X represents Cl, Br, C1-3 alkyl sulfonate or C6-10 arγl sulfonate; to produce (S)-2-[1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]-3- pyrrolidinyl]-2,2-diphenylacetamide (Darifenacin) (Ia), (ix) treating (S)-2-[1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]-3-pyrrolidinyl]- 2,2-diphenylacetamide (Darifenacin) (Ia) with an acid in a solvent and water mixture, (x) isolating pure (S)-2-[1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]-3- pyrrolidinyl]-2,2-diphenylacetamide (Darifenacin) (Ia), (xi) treating pure Darifenacin (Ia) with HBr to produce Darifenacin hydrobromide (I).

  本发明涉及一种改进的制备Darifenacin hydrobromide（I）的过程。 (i) 在溶剂中，将3-(S)-(-)-1l-氨基-1,1-二苯甲基吡咯烷（III）或其盐与化合物XIII的化合物在碱的存在下缩合，其中X代表Cl、Br、C1-3烷基磺酸盐或C6-10芳基磺酸盐；以产生(S)-2-[1-[2-(2,3-二氢苯并呋喃-5-基)乙基]-3-吡咯基]-2,2-二苯乙酰胺（Darifenacin）（Ia），(ix) 在溶剂和水混合物中用酸处理(S)-2-[1-[2-(2,3-二氢苯并呋喃-5-基)乙基]-3-吡咯基]-2,2-二苯乙酰胺（Darifenacin）（Ia），(x) 分离纯净的(S)-2-[1-[2-(2,3-二氢苯并呋喃-5-基)乙基]-3-吡咯基]-2,2-二苯乙酰胺（Darifenacin）（Ia），(xi) 用HBr处理纯净的Darifenacin（Ia）以产生Darifenacin hydrobromide（I）。
• Preparation of substituted quinazolines
  申请人：——

  公开号：US20040158065A1

  公开（公告）日：2004-08-12

  Methods and materials for preparing irreversible inhibitors of tyrosine kinases of general Formula 1 are disclosed. Such inhibitors, which include N-[4-(3-chloro-4-floro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide, are useful for treating cancer, restenosis, atherosclerosis, endometriosis and psoriasis. The disclosed methods employ protecting schemes to minimize undesirable diacryloylamino-quinazoline side products. 1

  揭示了制备一般化合物1的酪氨酸激酶不可逆抑制剂的方法和材料。这些抑制剂包括N-[4-(3-氯-4-氟苯胺基)-7-(3-吗啉-4-基-丙氧基)-喹唑啉-6-基]-丙烯酰胺，可用于治疗癌症、再狭窄、动脉粥样硬化、子宫内膜异位症和牛皮癣。揭示的方法采用保护方案以减少不良的双丙烯酰胺基喹唑啉副产物。
• Wielstra, Ytsen; Gambarotta, Sandro; Spek, Anthony L., Organometallics, 1990, vol. 9, # 7, p. 2142 - 2148
  作者：Wielstra, Ytsen、Gambarotta, Sandro、Spek, Anthony L.、Smeets, Wilberth J. J.

  DOI：——

  日期：——
• Wittig olefination via reaction of fluorine-containing phosphoranium salts and F-acyl fluorides. A new approach to fluoroolefin synthesis
  作者：Donald J. Burton、Daryl G. Cox

  DOI：10.1021/ja00341a070

  日期：1983.2
• WARNER, PHILIP;CHU, I-SHAN;BOULANGER, WILLIAM, TETRAHEDRON LETT., 1983, 24, N 39, 4165-4168
  作者：WARNER, PHILIP、CHU, I-SHAN、BOULANGER, WILLIAM

  DOI：——

  日期：——