2-(N-(2-tert-butyldimethylsilyloxyethyl)-2-hydroxyethylamino)ethanol | 1222450-74-9

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 2-(N-(2-tert-butyldimethylsilyloxyethyl)-2-hydroxyethylamino)ethanol
• 英文别名: 2,2'-([2-(tert-Butyldimethylsilyloxy)ethyl]azanediyl)diethanol；2-[2-[tert-butyl(dimethyl)silyl]oxyethyl-(2-hydroxyethyl)amino]ethanol
• CAS: 1222450-74-9
• 化学式: C₁₂H₂₉NO₃Si
• 分子量: 263.453
• InChiKey: AIZYQQWGMSQSDP-UHFFFAOYSA-N

物化性质

• 沸点：
  328.7±22.0 °C(Predicted)
• 密度：
  0.972±0.06 g/cm3(Predicted)
• 保留指数：
  1698

计算性质

• 辛醇/水分配系数(LogP)：
  1.29
• 重原子数：
  17
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-羟基邻苯二甲酰亚胺 、 2-(N-(2-tert-butyldimethylsilyloxyethyl)-2-hydroxyethylamino)ethanol 在 偶氮二甲酸二异丙酯 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 以82%的产率得到N,N-bis(2-phthalimidooxyethyl)-2-(tert-butyldimethylsilyloxy)ethyl amine
  参考文献：
  名称：

  Nucleophilic cationization reagents

  摘要：

  Nucleophilic cationization reagents fitted with aminooxy groups are described. Practical syntheses of mono- and bis-aminooxy tetraalkylammonium iodides including N-hydroxyethyl-functionalized analogs are reported. An oximation example using one of the reagents is presented to illustrate their use in synthesis of cationic materials. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.01.094
• 作为产物：
  描述：

  三乙醇胺 、 叔丁基二甲基氯硅烷 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以90%的产率得到2-(N-(2-tert-butyldimethylsilyloxyethyl)-2-hydroxyethylamino)ethanol
  参考文献：
  名称：

  Nucleophilic cationization reagents

  摘要：

  Nucleophilic cationization reagents fitted with aminooxy groups are described. Practical syntheses of mono- and bis-aminooxy tetraalkylammonium iodides including N-hydroxyethyl-functionalized analogs are reported. An oximation example using one of the reagents is presented to illustrate their use in synthesis of cationic materials. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.01.094

文献信息

• NANOPARTICLES FOR DRUG DELIVERY
  申请人：Nantz Michael H.

  公开号：US20120302516A1

  公开（公告）日：2012-11-29

  The invention provides magnetic nanoparticles comprising a core, wherein the nanoparticles comprise at least one therapeutic agent linked to the core via a hydrazone linkage or via an oxime ether linkage, methods for making said nanoparticles, and methods for using said nanoparticles.

  该发明提供了磁性纳米颗粒，包括一个核心，其中纳米颗粒通过肼酰肼键或肟醚键与至少一种治疗剂连接，制备该纳米颗粒的方法以及使用该纳米颗粒的方法。
• [EN] METHODS FOR DIAGNOSIS AND TREATMENT OF PULMONARY HYPERTENSION<br/>[FR] MÉTHODES DE DIAGNOSTIC ET DE TRAITEMENT DE L'HYPERTENSION PULMONAIRE
  申请人：[en]THE METHODIST HOSPITAL SYSTEM

  公开号：WO2024025991A1

  公开（公告）日：2024-02-01

  A method is disclosed of detecting a disease associated with pulmonary vascular remodeling in a subject. The method can comprise administering to the subject a compound of Formula I or Formula II. The method can further comprise imaging the compound in lungs of the subject using positron emission tomography to determine uptake of the compound in pulmonary vasculature of the lungs, wherein retention of the compound in the pulmonary vasculature reflects vascular remodeling. Methods of treating a disease associated with pulmonary vascular remodeling or for imaging a pulmonary vasculature in a subject are also provided.
• Nucleophilic cationization reagents
  作者：Souvik Biswas、Xuan Huang、Wesley R. Badger、Michael H. Nantz

  DOI：10.1016/j.tetlet.2010.01.094

  日期：2010.3

  Nucleophilic cationization reagents fitted with aminooxy groups are described. Practical syntheses of mono- and bis-aminooxy tetraalkylammonium iodides including N-hydroxyethyl-functionalized analogs are reported. An oximation example using one of the reagents is presented to illustrate their use in synthesis of cationic materials. (C) 2010 Elsevier Ltd. All rights reserved.