N-(p-methoxytrityl)-γ-aminobutyric acid methyl ester

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: N-(p-methoxytrityl)-γ-aminobutyric acid methyl ester
• 英文别名: Methyl 4-[[(4-methoxyphenyl)-diphenylmethyl]amino]butanoate；methyl 4-[[(4-methoxyphenyl)-diphenylmethyl]amino]butanoate
• 化学式: C₂₅H₂₇NO₃
• 分子量: 389.494
• InChiKey: VGIZXCKYEKYUCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  29
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(p-methoxytrityl)-γ-aminobutyric acid methyl ester 、 碘甲烷 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Cephalosporin prodrugs of paclitaxel for immunologically specific activation by L-49-sFv-β-Lactamase fusion protein

  摘要：

  Paclitaxel conjugates of 7-phenylacetamidocephalosporanic acid were prepared as prodrugs for site specific activation by targeted beta-lactamase. Immunologically specific activation of the prodrug 5 containing 3,3-dimethyl-4-amino-butyric acid as linker in combination with the fusion protein L-49-sFv-beta-lactamase was demonstrated in vitro on 3677 melanoma cells. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00935-6
• 作为产物：
  描述：

  4-氨基丁酸甲酯盐酸盐 、 4-甲氧基三苯基氯甲烷 在 三乙胺 作用下， 反应 14.0h， 以96%的产率得到N-(p-methoxytrityl)-γ-aminobutyric acid methyl ester
  参考文献：
  名称：

  Cephalosporin prodrugs of paclitaxel for immunologically specific activation by L-49-sFv-β-Lactamase fusion protein

  摘要：

  Paclitaxel conjugates of 7-phenylacetamidocephalosporanic acid were prepared as prodrugs for site specific activation by targeted beta-lactamase. Immunologically specific activation of the prodrug 5 containing 3,3-dimethyl-4-amino-butyric acid as linker in combination with the fusion protein L-49-sFv-beta-lactamase was demonstrated in vitro on 3677 melanoma cells. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00935-6

文献信息

• Cephalosporin prodrugs of paclitaxel for immunologically specific activation by L-49-sFv-β-Lactamase fusion protein
  作者：Vivekananda M. Vrudhula、David E. Kerr、Nathan O. Siemers、Gene M. Dubowchik、Peter D. Senter

  DOI：10.1016/s0960-894x(02)00935-6

  日期：2003.2

  Paclitaxel conjugates of 7-phenylacetamidocephalosporanic acid were prepared as prodrugs for site specific activation by targeted beta-lactamase. Immunologically specific activation of the prodrug 5 containing 3,3-dimethyl-4-amino-butyric acid as linker in combination with the fusion protein L-49-sFv-beta-lactamase was demonstrated in vitro on 3677 melanoma cells. (C) 2002 Elsevier Science Ltd. All rights reserved.