[3-(羟甲基)-1-氧杂-4-氮杂螺[4.5]癸烷-3-基]甲醇 | 63478-84-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 中文名称: [3-(羟甲基)-1-氧杂-4-氮杂螺[4.5]癸烷-3-基]甲醇
• 英文名称: 2,2'-bis(hydroxymethyl)-1-aza-4-oxaspirodecane
• 英文别名: (1-oxa-4-aza-spiro[4.5]decane-3,3-diyl)-bis-methanol；3,3-bis-hydroxymethyl-1-oxa-4-aza-spiro[4.5]decane；3,3-Bis-hydroxymethyl-1-oxa-4-aza-spiro[4.5]decan；3,3-Bismethylol-1,4-oxaazaspiro<4.5>decan；1-Oxa-4-azaspiro[4.5]decane-3,3-dimethanol；[3-(hydroxymethyl)-1-oxa-4-azaspiro[4.5]decan-3-yl]methanol
• CAS: 63478-84-2
• 化学式: C₁₀H₁₉NO₃
• mdl: MFCD00457531
• 分子量: 201.266
• InChiKey: KAEFUAJBLZQMTF-UHFFFAOYSA-N

物化性质

• 熔点：
  113 °C
• 沸点：
  364.6±32.0 °C(Predicted)
• 密度：
  1.20±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  61.7
• 氢给体数：
  3
• 氢受体数：
  4

安全信息

• 海关编码：
  2934999090
• 储存条件：
  2-8℃

反应信息

• 作为反应物：
  描述：

  [3-(羟甲基)-1-氧杂-4-氮杂螺[4.5]癸烷-3-基]甲醇 、 四乙二醇二对甲苯磺酸酯 在 氢氧化钾 作用下， 以 1,4-二氧六环 为溶剂， 反应 10.0h， 以38%的产率得到10,13,16,19,22,25-Hexaoxa-7-aza-dispiro[5.1.15.2]pentacosane
  参考文献：
  名称：

  α-Amino acids and dioxopiperazines crowned at the α-carbons with polyether macrorings. Synthesis, complexation and self-assembling properties

  摘要：

  Crowned alpha-amino acids 7a-c and their dioxopiperazine derivatives 12a-c were prepared from the easily accessible masked tris(hydroxymethyl)aminomethane 1. X-Ray crystal structures of the free as well as alkali metal ion coordinated compounds were investigated. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(02)01065-7
• 作为产物：
  描述：

  环己酮 、 三羟甲基氨基甲烷 以 甲苯 为溶剂， 以86%的产率得到[3-(羟甲基)-1-氧杂-4-氮杂螺[4.5]癸烷-3-基]甲醇
  参考文献：
  名称：

  Synthesis and Stereochemistry of Some 1,3-Oxazolidine Systems Based on TRIS (α,α,α-Trimethylolaminomethane) and Related Aminopolyols Skeleton. Part 1: (Di)spiro-1,3-oxazolidines

  摘要：

  Synthesis of the title compounds is examined from the diastereoselectivity point of view; their stereochemical assignments are supported by high resolution NMR data, which are used to define their chirality and isomerisation aspects. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00268-4

文献信息

• Synthesis and Stereochemistry of Some 1,3-Oxazolidine Systems Based on TRIS (α,α,α-trimethylolaminomethane) and Related Aminopolyols Skeleton. Part 2: 1-Aza-3,7-dioxabicyclo[3.3.0]octanes
  作者：Mircea Darabantu、Gérard Plé、Carmen Maiereanu、Ion Silaghi-Dumitrescu、Yvan Ramondenc、Sorin Mager

  DOI：10.1016/s0040-4020(00)00264-7

  日期：2000.6

  The reaction of TRIS with equivalent amounts of two carbonyl compounds is shown to afford, diastereoselectively, the title compounds. The results are discussed as a synthetic strategy and the stereochemistry is supported by theoretical calculations and high resolution NMR data.

  显示TRIS与等量的两种羰基化合物的反应非对映选择性地提供标题化合物。结果作为合成策略进行了讨论，并且立体化学得到理论计算和高分辨率NMR数据的支持。
• Synthetic studies of carbohydrate derivatives by photochemical reactions. Part 16. Synthesis of DL-apiose derivatives by photochemical cycloaddition of 1,3-dihydroxypropan-2-one derivatives with ethenediol or ethenol derivatives
  作者：Younosuke Araki、Jun-ichi Nagasawa、Yoshiharu Ishido

  DOI：10.1039/p19810000012

  日期：——

  e (45)(19% yield), respectively. The reaction of (5) with (43) was also induced thermally to give ethyl 4-acetoxy-3-(acetoxymethyl)coronate (46)(24% yield) in addition to (45)(20% yield). Photocycloaddition of diethyl mesoxalate (21) with (6) gave diethyl 3-oxo-2,4,6-trioxabicyclo[3.2.0]heptane-7,7-dicarboxylate (22)(23% yield). On the other hand, the reactions of 1,3-dimethoxy-(8) and 1,3-bis(ben

  用高压汞灯照射1,3-二乙酰氧基丙-2-酮（5）和1,3-二氧杂-2-酮（6）的苯溶液得到光环加成产物（7-乙酰氧基甲基-3-氧代2,4,6-三氧杂双环[3.2.0]庚烷-7-基）-乙酸甲酯（7）（55％收率）。（5）与（Z）-乙烯基二乙酸乙烯酯（23），与（Z）-2-（苄氧基）乙酸乙烯酯（25），2,3-二氢-1,4-二恶英（27）和乙酸乙烯酯（28），乙酸异丙烯酯（29），乙氧基乙烯（30）和1,1-二乙氧基乙烯（43）得到顺式-4,4-双（乙酰氧基甲基）氧杂环丁烷-2,3-二乙酸二乙酸酯（31 ）（46％的收率）和反式-异构体（32）（49％产率）; 2,2-双（乙酰氧基甲基）-4-（苄氧基）-氧杂-3-乙酸乙酸酯（33）（由两种异构体组成;产率分别为11％和26％）和4,4-双-（乙酰氧基甲基）-3 -（苄氧基）氧杂-2-烷基乙酸酯（38）（由两种异构体组成；产率为11％和9％）；（8-乙酰氧基甲基-2
• Towards peptide versions of Cram's host–guest chemistry: the synthesis of Cα,α-disubstituted glycines with binaphthol-based crowned side-chains
  作者：J MAZALEYRAT、K WRIGHT、M AZZINI、A GAUCHER、M WAKSELMAN

  DOI：10.1016/s0040-4039(03)00127-8

  日期：2003.2.24

  α,α-disubstituted α-amino acids or their precursors, possessing either an achiral frame derived from α-hydroxymethylserine, or a 2,2′,6,6′-tetrasubstituted biphenyl frame with only an axial chirality, or a frame with α-carbon chirality derived from α-methyl-(L)-DOPA, using (R)-2,2′-bis-(5-tosyloxy-3-oxa-1-pentyloxy)-1,1′-binaphthyl as alkylating agent, gave a new series of amino acids bearing binaphthol-based

  各种α，α-二取代的α-氨基酸或其前体的羟基的二醚化，其具有衍生自α-羟甲基丝氨酸的非手性骨架或仅具有轴向的2,2'，6,6'-四取代的联苯骨架（R）-2,2'-双-（5-甲苯磺酰氧基-3-氧杂-1-戊氧基）-1衍生自α-甲基-（L）-DOPA的具有α-碳手性的骨架， 1'-联萘作为烷基化剂，产生了一系列带有联萘酚基冠醚的氨基酸，作为构建具有拓扑结构良好定位的受体的短链肽螺旋的基础。
• Candle wax stabilized with oxazolidines
  申请人：——

  公开号：US20030000128A1

  公开（公告）日：2003-01-02

  White, dyed, dipped, unscented and/or scented candle wax is effectively stabilized against discoloration and fading by the incorporation therein of an oxazolidine in combination with a UV absorber and/or an antioxidant.

  白色、染色、浸渍、无味和/或有香味的蜡烛蜡通过添加一种氧杂环己烷与UV吸收剂和/或抗氧化剂的组合物，可以有效地稳定其颜色和防止褪色。
• 1-Oxa-4-azaspiro[4,5]decanes as light stabilizers for polymers
  申请人：American Cyanamid Company

  公开号：US04125518A1

  公开（公告）日：1978-11-14

  This invention relates to the use of 1-oxa-4-azaspiro[4,5]decanes as light stabilizers for polymers.

  本发明涉及使用1-氧杂-4-氮杂螺[4,5]癸烷作为聚合物的光稳定剂。