2,6-bis(4-fluorophenyl)-3-methyl-4-piperidone | 475474-45-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2,6-bis(4-fluorophenyl)-3-methyl-4-piperidone
• 英文别名: 2,6-bis(4-fluorophenyl)-3-methylpiperidin-4-one
• CAS: 475474-45-4
• 化学式: C₁₈H₁₇F₂NO
• 分子量: 301.336
• InChiKey: FRJWDLSUARCCMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.95
• 重原子数：
  22.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  29.1
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  2,6-bis(4-fluorophenyl)-3-methyl-4-piperidone 在 sodium acetate 作用下， 以 乙醇 为溶剂， 反应 6.0h， 生成 3-(2,6-bis(4-fluorophenyl)-3-methylpiperidin-4-ylideneamino)-2-thioxoimidazolidin-4-one
  参考文献：
  名称：

  A facile microwave assisted green chemical synthesis of novel piperidino 2-thioxoimidazolidin-4-ones and theirin vitromicrobiological evaluation

  摘要：

  A series of novel hybrid heterocyclic compounds, 3-(3-alkyl-2,6-diarylpiperin-4-ylidene)-2-thioxoimidazolidin-4-ones were synthesised and a comparative study was also carried out under microwave irradiation. The synthesised compounds were characterised by their melting points, elemental analysis, MS, FT-IR, one-dimensional NMR (1H, D2O exchanged 1H and

  DOI：

  10.3109/14756361003691878
• 作为产物：
  描述：

  在 氨 作用下， 以 水 为溶剂， 生成 2,6-bis(4-fluorophenyl)-3-methyl-4-piperidone
  参考文献：
  名称：

  Synthesis, spectral analysis and in vitro microbiological evaluation of 3-(3-alkyl-2,6-diarylpiperin-4-ylidene)-2-thioxoimidazolidin-4-ones as a new class of antibacterial and antifungal agents

  摘要：

  In the present work, a new series of bis hybrid heterocycle comprising both piperidine and thiohydantoin nuclei together namely 3-(3-alkyl-2,6-diarylpiperin-4-ylidene)-2-thioxoimidazolidin-4-ones 46-60 was synthesized by the treatment of the respective thiosemicarbazones 31-45 with chloroethyl acetate and anhydrous sodium acetate in refluxing ethanol for 4 h and were characterized by melting point, elemental analysis, MS, FT-IR, one-dimensional NMR (H-1, D2O exchanged H-1 and C-13), two dimensional HOMOCOSY and NOESY spectroscopic data. In addition, the title compounds were screened for their antimicrobial activities against a spectrum of clinically isolated microbial organisms. Compounds 47-50, 52-55 and 57-60 with fluoro, chloro, methoxy or methyl functions at the para position of phenyl rings attached to C-2 and C-6 carbons of piperidine moiety along with and without methyl substituent at position C-3 of the piperidine ring exerted potent biological activities againstStaphylococcus aureus, beta-Hemolytic streptococcus, Vibrio cholerae, Escherichia coli, Pseudomonas aeruginosa, Aspergillus flavus, Candida albicans, Candida 6 and Candida 51 at a minimum inhibitory concentration. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.11.074

文献信息

• Synthesis, characterization, crystal structure, in-vitro antimicrobial evaluation and molecular docking studies of 1-(furan-2-carbonyl)-3-alkyl-2,6-diphenylpiperidin-4-one derivatives
  作者：R. Srikanth、A. Sivarajan、C.S. Venkatesan、V. Maheshwaran、P. Sugumar、G. Rajitha、J.C. Varalakshmi、M.N. Ponnuswamy

  DOI：10.1016/j.molstruc.2016.07.023

  日期：2016.12

  Abstract A new class of various furoyl derivatives of 2,6-disubstituted piperidin-4-ones were synthesized and characterized by FTIR, NMR, mass and single crystal X-ray diffraction methods. The synthesized compounds were subjected to in-vitro antibacterial and antifungal activities against pathogenic microbial strains. The results pointed out that compounds 11, 12 & 14 displayed pronounced activity

  摘要 合成了一类新的2,6-二取代哌啶-4-酮的呋喃酰基衍生物，并采用FTIR、NMR、质谱和单晶X射线衍射方法对其进行了表征。合成的化合物对病原微生物菌株进行体外抗菌和抗真菌活性。结果表明化合物11、12和14对革兰氏阳性菌显示出明显的活性，而化合物9、13和14对革兰氏阴性菌显示出优异的抑制活性。化合物9对真菌表现出中等活性。此外，还进行了分子对接实验。
• Stereoselective synthesis and spectral studies of some benzotriazolylacetyl hydrazones of 3–alkyl–2,6–diarylpiperidin–4–ones
  作者：M. Velayutham Pillai、K. Rajeswari、C. Udhaya Kumar、K. Gokula Krishnan、S. Mahendran、C. Ramalingan、E.R. Nagarajan、T. Vidhyasagar

  DOI：10.1016/j.molstruc.2017.09.010

  日期：2017.12

  benzotriazole nucleus into piperidine ring is achieved through hydrazone formation. The characterization of the synthesized compounds was carried out using FT-IR, 1H &13C NMR, 1H–1H COSY, 1H–13C COSY, NOESY spectral techniques and GC-Mass spectrum. The spectral assignments were done without ambiguity using 2D-NMR techniques. The conformational preference of the piperidine ring deduced from the spectral

  摘要 通过腙的形成，努力将具有生物活性的苯并三唑核包含在哌啶环中。合成化合物的表征使用 FT-IR、1H 和 13C NMR、1H-1H COSY、1H-13C COSY、NOESY 光谱技术和 GC-质谱进行。使用 2D-NMR 技术毫无歧义地完成了光谱分配。从光谱研究中推导出的哌啶环的构象偏好是“椅子”。分子中存在的亚甲基质子/甲基的非对映性质在观察到的光谱模式中清楚地显示出来。
• Synthesis, stereochemical, structural and biological studies of some 2,6-diarylpiperidin-4-one N(4′)-cyclohexyl thiosemicarbazones
  作者：A. Sethukumar、C. Udhaya Kumar、R. Agilandeshwari、B. Arul Prakasam

  DOI：10.1016/j.molstruc.2013.05.008

  日期：2013.9

  Abstract A new series of 2,6-diarylpiperidin-4-one N(4′)-cyclohexyl thiosemicarbazones (13–23) were synthesized by corresponding 2,6-diarylpiperidin-4-ones (1–11) reaction with cyclohexyl thiosemicarbazide (12). The chemical structures were confirmed by means of IR, one and two dimensional NMR, Mass spectra and single crystal X-ray diffraction analysis. Compounds 13–23, exist in chair conformation

  摘要 通过相应的 2,6-二芳基哌啶-4-酮 (1-11) 与环己基氨基硫脲 (Semicarbazide) 反应合成了一系列新的 2,6-二芳基哌啶-4-one N(4')-环己基缩氨基硫脲 (13-23)。 12)。通过红外、一维和二维核磁共振、质谱和单晶X射线衍射分析证实了化学结构。化合物 13-23 以椅子构象存在，除化合物 21-23 的 C-5 处的甲基外，所有哌啶环上的取代基均呈赤道取向，以轴向排列以稳定椅子构象。化合物 18 的单晶 X 射线结构分析，证明 CN 双键的构型与 C-5 碳（E 型）同构。对所有合成的化合物进行了生物活性筛选。
• Stereoselective synthesis, spectral and antimicrobial studies of some cyanoacetyl hydrazones of 3-alkyl-2,6-diarylpiperidin-4-ones
  作者：M. Velayutham Pillai、K. Rajeswari、T. Vidhyasagar

  DOI：10.1016/j.molstruc.2014.07.050

  日期：2014.11

  Abstract A series of novel cyanoacetyl hydrazones of 3-alkyl-2,6-diarylpiperidin-4-ones were synthesized stereoselectively and characterized by IR, Mass, 1 H NMR, 13 C NMR, 1 H– 1 H COSY and 1 H– 13 C COSY spectra. The stereochemistry of the synthesized compounds was established using NMR spectra. Antimicrobial screening of the synthesized compounds revealed their antibacterial and antifungal potencies

  摘要 立体选择性地合成了一系列 3-烷基-2,6-二芳基哌啶-4-酮的新型氰基乙酰腙，并通过红外、质谱、 1 H NMR、 13 C NMR、 1 H– 1 H COZY 和 1 H– 13 表征。 C 舒适光谱。合成化合物的立体化学是通过核磁共振谱确定的。合成化合物的抗菌筛选揭示了它们的抗菌和抗真菌效力。发现化合物 15 对产气肠杆菌的生长抑制优于标准药物。
• Chemoselective synthesis and spectral studies of <i>N</i>-thiocyanatoacetyl derivatives of 3-alkyl-2,6-diarylpiperidin-4-ones
  作者：M. Velayutham Pillai、K. Rajeswari、C. Udhaya Kumar、C. Ramalingan、A. Manohar、T. Vidhyasagar

  DOI：10.1080/10426507.2016.1149852

  日期：2016.9.1

  of the respective piperidin–4–ones and the ambident thiocyanate nucleophile. The synthesized compounds have been characterized through FT–IR, 1H, 13C, 1H–1H COSY, 1H–13C COSY and NOESY spectra. The spectral data reveal the conformational priority of the six-membered heterocyclic ring.

  图形摘要 摘要 3-烷基-2,6-二芳基哌啶-4-酮的一系列N-硫氰酸根合乙酰基衍生物已通过各自哌啶-4-酮的N-氯乙酰衍生物与中间硫氰酸酯亲核试剂之间的反应合成。合成的化合物已通过 FT-IR、1H、13C、1H-1H COSY、1H-13C COSY 和 NOESY 光谱进行表征。光谱数据揭示了六元杂环的构象优先级。