tropane-3-carboxamide | 116568-67-3

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 托烷生物碱
• 英文名称: tropane-3-carboxamide
• 英文别名: Tropan-3-carbamid；8-Methyl-8-azabicyclo[3.2.1]octane-3-carboxamide
• CAS: 116568-67-3
• 化学式: C₉H₁₆N₂O
• 分子量: 168.239
• InChiKey: FUAAUIBWWDXITO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  tropane-3exo-carboxylic acid methyl ester 在 氨 、 sodium methylate 作用下， 生成 tropane-3-carboxamide
  参考文献：
  名称：

  The Action of Nucleophilic Agents on 3α-Chlorotropane¹

  摘要：

  DOI：

  10.1021/ja01550a064

文献信息

• Compounds, Compositions and Methods for Treatment of Myopia
  申请人：Aerie Pharmaceuticals, Inc.

  公开号：US20200247760A1

  公开（公告）日：2020-08-06

  Provided herein are 8-methyl-8-azabicyclo[3.2.1]octan-3-yl and pyridin-4-ylmethanyl ester and amide compounds and compositions. Also provided herein are methods of preventing or delaying the onset of myopia in a subject in need thereof, comprising administering the compounds or compositions provided herein to the subject. Also provided herein are methods of reducing or preventing the progression of myopia in a subject in need thereof, comprising administering the compounds or compositions provided herein to the subject.

  本文提供了8-甲基-8-氮杂双环[3.2.1]辛烷-3-基和吡啶-4-甲基酯和酰胺化合物及其组合物。本文还提供了一种预防或延迟需要该治疗的患者近视发生的方法，包括向该患者施用本文提供的化合物或组合物。本文还提供了一种减缓或预防需要该治疗的患者近视进展的方法，包括向该患者施用本文提供的化合物或组合物。
• [EN] A PROCESS FOR THE SYNTHESIS OF MARAVIROC<br/>[FR] PROCÉDÉ DE SYNTHÈSE DE MARAVIROC
  申请人：ZENTIVA KS

  公开号：WO2014173375A1

  公开（公告）日：2014-10-30

  A process for the synthesis of Maraviroc The invention relates to a new approach to synthesis of Maraviroc, a substance with the chemical name N-(lS)-3-[3-(3-isopropy)-5- methyl-4 H-l,2,4-triazol-4-yl-exo-8-azabicyclo-[3.2.1]oct-8-yl]-l- phenylpropyl}-4,4-difluorocyclohexanecarboxamide and the structure of formula I using the "borrowing hydrogen" method also called "hydrogen autotransfer" method as well as improved isolation and purification of the final product.

  一种合成马拉维罗克的方法 本发明涉及一种合成马拉维罗克的新方法，该物质的化学名称为N-(lS)-3-[3-(3-异丙基)-5-甲基-4 H-1,2,4-三唑-4-基-外-8-氮杂双环[3.2.1]辛-8-基]-1-苯基丙基}-4,4-二氟环己烷羧酰胺，结构式为I，使用“借氢”法，也称为“氢自转移”法，以及改进的终产品的分离和纯化方法。
• N-Benzyltropaneamides
  申请人：G.D. Searle & Co.

  公开号：EP0416521A1

  公开（公告）日：1991-03-13

  N-benzyl tropane amides, which have activity as Class III antiarrhythmic agents, acting by prolonging cardiac action potential repolarization. The invention further provides for compositions incorporating the compounds and methods of their use, as well as providing for pharmaceutically acceptable salts of the compounds.

  N-苄基托烷酰胺，具有作为 III 类抗心律失常药物的活性，通过延长心脏动作电位复极化发挥作用。本发明还提供了包含这些化合物的组合物及其使用方法，以及这些化合物的药学上可接受的盐类。
• Compounds, compositions and methods for treatment of myopia
  申请人：Aerie Pharmaceuticals, Inc.

  公开号：US11117869B2

  公开（公告）日：2021-09-14

  Provided herein are 8-methyl-8-azabicyclo[3.2.1]octan-3-yl and pyridin-4-ylmethanyl ester and amide compounds and compositions. Also provided herein are methods of preventing or delaying the onset of myopia in a subject in need thereof, comprising administering the compounds or compositions provided herein to the subject. Also provided herein are methods of reducing or preventing the progression of myopia in a subject in need thereof, comprising administering the compounds or compositions provided herein to the subject.

  本文提供了8-甲基-8-氮杂双环[3.2.1]辛烷-3-基和吡啶-4-基甲烷酯和酰胺化合物及组合物。本文还提供了预防或延迟有需要的受试者近视发生的方法，包括向受试者施用本文提供的化合物或组合物。本文还提供了减少或预防有需要的受试者近视发展的方法，包括对受试者施用本文提供的化合物或组合物。
• A PROCESS FOR THE SYNTHESIS OF MARAVIROC
  申请人：Zentiva K.S.

  公开号：EP2989099A1

  公开（公告）日：2016-03-02