copper (I) cyanide di(lithium chloride)complex | 59219-07-7

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: copper (I) cyanide di(lithium chloride)complex
• 英文别名: copper(I) cyanide di(lithium chloride) complex；CuCN*2LiCl；cuprous cyanide*2LiCl；Lithium;chlorocopper;cyanide
• CAS: 59219-07-7
• 化学式: CN*2Cl*Cu*2Li
• 分子量: 174.352
• InChiKey: KSRNRXBEAMJLPW-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -5.9
• 重原子数：
  5
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  copper (I) cyanide di(lithium chloride)complex 、 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Total Synthesis of Lucilactaene, A Cell Cycle Inhibitor Active in p53-Inactive Cells

  摘要：

  Hetero-bis-metalated 1,3-butadiene is employed in the lynchpin coupling of synthetic fragments of the side chain of the antitumor agent, lucilactaene. Sequential Stille and Suzuki-Miyaura couplings interpolate this unique boron/tin diene into the pentaene chain. The total synthesis of lucilactaene was accomplished efficiently, in just eight linear steps.

  DOI：

  10.1021/ja056217g
• 作为产物：
  描述：

  copper(l) cyanide 、 lithium chloride 反应 2.0h， 生成 copper (I) cyanide di(lithium chloride)complex
  参考文献：
  名称：

  黄体素的对映选择性合成

  摘要：

  据报道对细胞生长抑制药和抗生素黄嘌呤（1a）的对映选择性合成。作为关键中间体，鉴定出了双环化合物2，它可以很容易地由非对映体和对映体纯形式的甲基-2-糠酸合成。化合物2可以在C-6和C-7上进行区域和立体选择性官能化，从而可以轻松引入xanthatin中的官能团及其衍生物的合成。此外，引入exo的稳健策略开发了许多倍半萜中常见的C-3上的亚甲基基团，利用邻皮戊酰基掩盖α，β-不饱和羰基系统中的烯烃，该基团在酸性和弱碱性条件下稳定，但在处理后被消除有很强的基础。

  DOI：

  10.1002/chem.201402735
• 作为试剂：
  描述：

  3-溴苄溴 、 N,N-二甲基-4-碘-1H-咪唑-1-磺酰胺 在 乙基溴化镁 、 copper (I) cyanide di(lithium chloride)complex 作用下， 以 乙醚 、 二氯甲烷 、 水 为溶剂， 反应 73.33h， 以46%的产率得到4-(3-溴苄基)咪唑-1-磺酸二甲基酰胺
  参考文献：
  名称：

  4-Benzyl-1H-imidazoles with Oxazoline Termini as Histamine H₃ Receptor Agonists

  摘要：

  Research on the therapeutic applications of the histamine H-3 receptor (H3R) has traditionally focused on antagonists/inverse agonists. In contrast, H3R acyonists have received less attention despite their potential use in several disease areas. The lower availability of H3R agonists not only hampers their full therapeutic exploration, it also prevents an unequivocal understanding of the structural requirements for H3R activation. In the light of these important issues, we present our findings on 4-benzyl-1H-imidazole-based H3R agonists. Starting from two high throughput screen hits (10 and 11), the benzyl side chain was altered with lipophilic groups using combinatorial and classical chemical approaches (compounds 12-31). Alkyne- or oxazolino-substituents gave excellent affinities and agonist activities up to the single digit nM range. Our findings further substantiate the growing notion that basic ligand sidechains are not necessary for H3R activation and reveal the oxazolino group as a hitherto unexplored functional group in H3R research.

  DOI：

  10.1021/jm7014149

文献信息

• Borylcyanocuprate in a One-Pot Carboboration by a Sequential Reaction with an Electron-Deficient Alkyne and an Organic Carbon Electrophile
  作者：Yuri Okuno、Makoto Yamashita、Kyoko Nozaki

  DOI：10.1002/anie.201005667

  日期：2011.1.24

  A key reactive species, lithium borylcyanocuprate, was isolated and fully characterized in a one‐pot carboboration of alkynes. The carboboration involves a boryllithium, CuCN⋅2 LiCl, an ester‐substituted alkyne, and an organic electrophile (see scheme). By changing the reaction temperature, the syn/anti ratio of the carboborated products can also be changed.

  分离出了关键的反应性物种硼氰基氰基硼酸锂，并通过炔烃的一锅碳硼化对其进行了充分表征。碳硼化涉及硼酸锂，CuCN⋅2LiCl，酯取代的炔烃和有机亲电试剂（请参见方案）。通过改变反应温度，顺式/反的carboborated产品的比率也可以改变。
• Ring-Opening of<i>N-tert</i>-Butanesulfinylethynylaziridines with Lithium Tris(dimethylphenylsilyl)zincate: Stereoselective Access to 4-Amino-1-allenylsilanes
  作者：Valentin N. Bochatay、Youssouf Sanogo、Fabrice Chemla、Franck Ferreira、Olivier Jackowski、Alejandro Pérez-Luna

  DOI：10.1002/adsc.201500347

  日期：2015.9.14

  N‐tert‐butanesulfinylethynylaziridines with lithium tris(dimethylphenylsilyl)zincate is reported. The reaction is demonstrated to be both stereoselective and stereospecific and to proceed through an anti‐SN2′ process. Further deprotection of the nitrogen atom under mild conditions allows access to 4‐amino‐1‐(dimethylphenylsilyl)allenes with high yields and levels of stereoselectivity.

  据报道，N-叔丁烷亚磺酰基乙炔基氮丙啶与三（二甲基苯基甲硅烷基）锌酸锂开环。该反应被证明既具有立体选择性也具有立体特异性，并且会通过抗-S N 2'过程进行。在温和条件下对氮原子进行进一步的脱保护，可以以高收率和立体选择性的水平获得4-氨基-1-（二甲基苯基甲硅烷基）丙烯。
• Facile Synthesis of Acylsilanes via Aerobic Oxidation of <i>g</i><i>em-</i>Disilylalkylcopper Compounds
  作者：Atsushi Inoue、Junichi Kondo、Hiroshi Shinokubo、Koichiro Oshima

  DOI：10.1021/ja016716r

  日期：2001.11.1