1,1,2,2-tetraethyldiphosphane | 3040-63-9

• 分子结构分类: 有机化合物 - 有机磷化合物
• 英文名称: 1,1,2,2-tetraethyldiphosphane
• 英文别名: Tetraaethyl-diphosphin；Tetraethyldiphosphin；Tetraethyldiphosphan；Tetraethyldiphosphine；diethylphosphanyl(diethyl)phosphane
• CAS: 3040-63-9
• 化学式: C₈H₂₀P₂
• mdl: MFCD02177507
• 分子量: 178.194
• InChiKey: UVTLTCJBYXBVBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1,1,2,2-tetraethyldiphosphane 在 sulfur 作用下， 生成 二乙基硫代膦酰-二乙基-硫代膦烷
  参考文献：
  名称：

  Issleib; Seidel, Chemische Berichte, 1959, vol. 92, p. 2681,2691

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 二氯甲烷 作用下， 生成 1,1,2,2-tetraethyldiphosphane
  参考文献：
  名称：

  CD4+ T-Lymphocytes Regulate Airway Remodeling and Hyper-Reactivity in a Mouse Model of Chronic Asthma

  摘要：

  Asthma is an acute-on-chronic inflammatory disease of the airways, characterized by airflow obstruction and hyper-reactivity of the airways to a variety of stimuli. Chronic asthma is associated with remodeling of the airway wall, which may contribute to hyper-reactivity and fixed airflow obstruction. We used an improved mouse model of chronic asthma to investigate the role of CD4(+) T-lymphocytes in airway remodeling and hyper-reactivity. Animals functionally depleted of CD4(+) T-lymphocytes by repeated administration of a monoclonal antibody exhibited markedly decreased airway responsiveness. In addition, these mice had greatly diminished subepithelial fibrosis, epithelial thickening, and mucous cell hyperplasia/metaplasia. Chronic inflammation in the airway wall was moderately reduced, with a marked decrease in the accumulation of immunoglobulin-synthesizing plasma cells. However, intraepithelial accumulation of eosinophils was not significantly inhibited and airway epithelial expression of eotaxin was undiminished. This work provides the first experimental evidence that CD4(+) T-lymphocytes play a crucial role in the pathogenesis of the lesions of chronic asthma and ends support to the notion that functional inhibition of these cells may be an important therapeutic target.

  DOI：

  10.1038/labinvest.3780438

文献信息

• Rh-catalyzed P–P bond activation
  作者：Stephen J. Geier、Douglas W. Stephan

  DOI：10.1039/b712972f

  日期：——

  A Rh-catalyst derived from (NacNac)Rh(COE)(N2) effects the hydrogenation and silylation of P–P bonds to give secondary phosphines and silylphosphines, (Ph2PH) and (Ph2PSiRR′2) respectively; the latter process is shown to also involve the silylation of secondary phosphines.

  由（NacNac）Rh（COE）（N2）衍生的Rh催化剂能够实现P–P键的氢化和硅烷化，分别生成二级膦Ph2PH和硅膦Ph2PSiRR′2；后者过程中还涉及二级膦的硅烷化。
• Kinetics and mechanism of the reaction of bis-μ-diethylphosphidobis(tetracarbonylmanganese) with tri-n-butylphosphine
  作者：Marino Basato

  DOI：10.1016/0022-328x(93)80470-v

  日期：1993.10

  high activation enthalpy (ΔH* = 165 kJ mol−1). The discriminating ability of the resulting coordinatively unsaturated intermediate [(OC)4 Mn(μ-PEt2)2Mn(CO)3] is only slightly in favour of attack of the more basic PnBu3 compared to CO, as indicated by the values of the competition rate ratio [k(CO)/k(PnBu3)=0.36-0.47]. This behaviour is compared with that of the isostructural chromium complex and discussed

  双核膦桥连的锰配合物[（OC）4的Mn（μ-PET 2）2的Mn（CO）4 ]用P经受热CO取代Ñ卜3在萘烷中，得到[（OC）4的Mn（μ-PET 2）2的Mn（CO）3（P ñ卜3）]和[（ñ卜3 P）（OC）3的Mn（μ-PET 2）2的Mn（CO）3（P ñ卜3）]。第一个CO / P n Bu 3的动力学研究交换表示正向和反向反应的所有取代均通过解离机理发生。CO的解离速率相当低（在130℃下k＝ 6.27×10 -5 s -1），主要是由于高的活化焓（ΔH * ＝ 165kJ mol -1）。所得配位不饱和中间体[（OC）的分辨力4的Mn（μ-PET 2）2的Mn（CO）3 ]仅稍微有利于更基本的P的攻击的Ñ卜3相比CO，如通过指示竞争率比值[ k（CO）/ k（P n Bu 3）＝ 0.36-0.47]。将该行为与同构铬配合物的行为进行了比较，并根据与这两种配合物中的金属-金属距离有关的电子和结构特征（Mn
• Novel Monophosphido-Bridged Diruthenium Complexes: Efficient Preparative Method and Catalytic Activity toward Reactions of Propargylic Alcohols with Aromatic Compounds
  作者：Yoshihiro Miyake、Satoshi Endo、Yohei Nomaguchi、Masahiro Yuki、Yoshiaki Nishibayashi

  DOI：10.1021/om8003465

  日期：2008.8.1

  chloride-bridged diruthenium(III) complex with (dialkylphosphino)trimethylsilanes afford novel monophosphido-bridged diruthenium complexes, which are further transformed into the corresponding cationic complexes by treatment with silver trifluoromethanesulfonate. The dimethylphosphido-bridged complex is found to work as a dual catalyst toward the redox isomerization of propargylic alcohols to α,β-unsaturated

  氯化物桥连的钌（III）配合物与（二烷基膦基）三甲基硅烷的反应提供了新颖的单磷酰基桥连的二钌配合物，其通过用三氟甲磺酸银处理而进一步转化为相应的阳离子配合物。发现二甲基磷酸酯桥联的络合物可作为双催化剂，使炔丙醇氧化还原异构化为α，β-不饱和酮，并与杂芳族化合物进行顺序Friedel-Crafts反应。
• Darstellung und NMR-spektroskopische charakterisierung einiger di-n-alkyl- und n-alkylaryl-chlorphosphane
  作者：W. Wolfsberger

  DOI：10.1016/0022-328x(86)80520-4

  日期：1986.12

  A series of di-n-alkyl and n-alkylaryl chlorophosphines has been prepared by the reaction of tetraorganodiphosphines with chlorodiphenyl or dichlorophenyl phosphine and characterized by 31P and 13C NMR spectra.

  通过使四有机二膦与氯二苯基或二氯苯基膦反应，制备了一系列的二正烷基和正烷基芳基氯膦，并通过31 P和13 C NMR光谱进行了表征。
• Phosphorus-31 and carbon-13 nuclear magnetic resonance studies of unsymmetrical tetra-alkyldiphosphanes R1R2PPMe2 and R1R2PPEt2
  作者：Ahmed A. M. Ali、Robin K. Harris

  DOI：10.1039/dt9880002775

  日期：——

  A series of unsymmetrical tetra-alkyldiphosphanes of general formulae R1R2PPMe2 and R1R2PPEt2(with R1, R2= Me, Et, Pri, But) have been obtained by scrambling reactions between the corresponding symmetrical diphosphanes in CH2Cl2 solution and have been studied by n.m.r. spectroscopy in situ. Values of 31P and 13C chemical shifts, together with (P,P) and (P,C) coupling constants, are reported and discussed

  一系列通式不对称四- alkyldiphosphanes的[R 1 - [R 2 PPME 2和R 1 - [R 2 PPET 2（其中R 1，R 2 =甲基，乙基，镨我，卜吨）已经由相应之间加扰反应得到在CH 2 Cl 2溶液中对称的二膦，并进行了核磁共振光谱的原位研究。的值31 P和13关于取代基效应和构象，报道并讨论了C化学位移以及（P，P）和（P，C）偶合常数。参数1 J PC + 2 J PC被证明是首选旋转异构体的良好预测指标，并且得出结论，1 J PC和2 J PC的符号必须相反。

表征谱图