甲基氢氧化汞(II) | 1184-57-2

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 中文名称: 甲基氢氧化汞(II)
• 中文别名: 甲基氢氧化汞；羟基甲基汞；甲基氢氧化汞,1M水溶液
• 英文名称: methylmercury(II) hydroxide
• 英文别名: Methylquecksilberhydroxyd；Methylquecksilberhydroxid；Methyl-mercurihydroxid；Hydroxymethylmercury；methylmercury(1+);hydroxide
• CAS: 1184-57-2
• 化学式: CH₄HgO
• 分子量: 232.632
• InChiKey: KRZWEBVPFGCYMY-UHFFFAOYSA-M

物化性质

• 熔点：
  137°C
• 沸点：
  39.8°C
• 暴露限值：
  ACGIH: TWA 0.01 mg/m3; STEL 0.03 mg/m3 (Skin)OSHA: Ceiling 0.04 mg/m3NIOSH: IDLH 2 mg/m3; IDLH 10 mg/m3; TWA 0.01 mg/m3; TWA 0.05 mg/m3; STEL 0.03 mg/m3; Ceiling 0.1 mg/m3
• 物理描述：
  Greenish-white powder or flakes with an unpleasant odor. (NTP, 1992)
• 溶解度：
  1 to 10 mg/mL at 70° F (NTP, 1992)
• 稳定性/保质期：
  避免与水溶液、碱金属、碱土金属以及许多有机和无机的活性化学药品接触。 会与碱性金属和碱金属发生反应。

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  3
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  1
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 危险等级：
  6.1
• 危险类别码：
  R26/27/28
• 海关编码：
  2931900090
• 危险类别：
  6.1
• 危险品运输编号：
  UN 2024
• 储存条件：
  密封储存，应存放在阴凉、干燥的仓库中。

SDS

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Section 1: Product Identification
Chemical Name: Methylmercury (II) hydroxide,approx. 1M aqueous solution
CAS Registry Number: 1184-57-2
Formula: CH3HgOH
EINECS Number: 214-667-2
Chemical Family: organomercury compound
Synonym: Methylmercury hydroxide

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Section 2: Composition and Information on Ingredients
Ingredient CAS Number Percent ACGIH (TWA) OSHA (PEL)
Title Compound 1184-57-2 23% 0.01mg/m3 0.01mg/m3
water 7732-18-5 77% no data no data

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Section 3: Hazards Identification
Mercury salts are poisonous by ingestion and inhalation of dust. Possible risk of harm to the unborn child.
Emergency Overview:
Prolonged exposure may cause heritable genetic damage and impaired fertility.
Primary Routes of Exposure: Ingestion, Skin.
Eye Contact: May cause mild to severe irritation of the eyes. May deposit mercury in the lens of the eye.
Skin Contact: May cause mild to severe irritation of the skin. Toxic in contact with skin.
May be toxic by inhalation. May cause severe respiratory and gastrointestinal distress. May damage the
Inhalation:
central nervous system.
Very toxic if swallowed. Lack of appetite, abdominal cramps, vomiting, kidney failure, paralysis. Mercury binds
Ingestion:
to thiol groups of protein.
Poison. stomach upset and pain, mouth pain, vomiting, excessive salivation, urine products appear in the
Acute Health Affects:
blood.
The chronic effects of mercury poisoning include stomatitis, tremors, psychic disturbances, excessive
Chronic Health Affects:
salivation, dermatitis, and pain on chewing. May cause heritable genetic damage and impair fertility.
NTP: No
IARC: Yes
OSHA: No

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SECTION 4: First Aid Measures
Immediately flush the eyes with copious amounts of water for at least 10-15 minutes. A victim may need
Eye Exposure:
assistance in keeping their eye lids open. Get immediate medical attention.
Wash the affected area with water. Remove contaminated clothes if necessary. Seek medical assistance if
Skin Exposure:
irritation persists.
Remove the victim to fresh air. Closely monitor the victim for signs of respiratory problems, such as difficulty
Inhalation:
in breathing, coughing, wheezing, or pain. In such cases seek immediate medical assistance.
Seek medical attention immediately. Keep the victim calm. Give the victim water (only if conscious). Induce
Ingestion:
vomiting only if directed by medical personnel.

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SECTION 5: Fire Fighting Measures
Flash Point: no data
Autoignition Temperature: none
Explosion Limits: none
Extinguishing Medium: carbon dioxide, foam or dry powder
If this product is involved in a fire, fire fighters should be equipped with a NIOSH approved positive pressure
Special Fire Fighting Procedures:
self- contained breathing apparatus and full protective clothing.
Hazardous Combustion and If involved in a fire this material may emit toxic fumes containing mercury.
Decomposion Products:
Unusual Fire or Explosion Hazards: No unusual fire or explosion hazards.

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SECTION 6: Accidental Release Measures
Small spills can be mixed with vermiculite, sodium carbonate or other suitable non combustible adsorbent and
Spill and Leak Procedures:
swept up.

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SECTION 7: Handling and Storage
Handling and Storage: Store in a cool, dry place in a tightly sealed container.

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SECTION 8: Exposure Controls and Personal Protection
Eye Protection: Always wear approved safety glasses when handling a chemical substance in the laboratory.
Skin Protection: Wear protective clothing and gloves.
Ventilation: If possible, handle the material in an efficient fume hood.
If ventilation is not available a respirator should be worn. The use of respirators requires a Respirator
Respirator:
Protection Program to be in compliance with 29 CFR 1910.134.
Ventilation: If possible, handle the material in an efficient fume hood.
Additional Protection: No additional protection required.

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SECTION 9: Physical and Chemical Properties
Color and Form: colorless liq.
Molecular Weight: 232.63
Melting Point: no data
Boiling Point: no data
Vapor Pressure: no data
Specific Gravity: no data
Odor: none
Solubility in Water: material is a water solution

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SECTION 10: Stability and Reactivity
Stability: air and moisture stable
Hazardous Polymerization: no hazardous polymerization
Conditions to Avoid: none
Incompatibility: azides, fulminates, active metals, reducing agents, and strong oxidizing agents.
Decomposition Products: carbon monoxide, carbon dioxide, mercury fumes, and organic fumes.

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SECTION 11: Toxicological Information
Oral (rat); LD50: 43300 ug/kg. Intraperitoneal (mouse); LD50: 20 mg/kg. Oral (monkey); LD: >3 mg/kg. Oral
(rat); TDLo: 315 mg/kg/30W-C. Subcutaneous (rat); TDLo: 70 mg/kg/7D-I. Oral (monkey); TDLo: 26320
RTECS Data: mg/kg/43W-I. Oral (rat); TDLo: 50 mg/kg. Subcutaneous (rat); TDLo:100 mg/kg. Human HeLa cell; DNA
inhibition: 10 umol/L. Human HeLa cell; Mutation test not-not otherwise specified: 7500 nmol/L. Intraperitoneal
(mouse); DNA inhibition: 1 mg/kg.
Carcinogenic Effects: No data
Mutagenic Effects: Mutagen
Tetratogenic Effects: Reproductive effector

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SECTION 12: Ecological Information
Avoid release to groundwater or waterways. Very toxic to aquatic organisms. May cause long-term adverse
Ecological Information:
effects.

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SECTION 13: Disposal Considerations
Disposal: Dispose of according to local, state and federal regulations.

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SECTION 14: Transportation
Shipping Name (CFR): Mercury compounds, liquid, N.O.S.
Hazard Class (CFR): 6.1
Additional Hazard Class (CFR): NA
Packaging Group (CFR): II
UN ID Number (CFR): UN# 2024
Shipping Name (IATA): Mercury compound, liquid, N.O.S.
Hazard Class (IATA): 6.1
Additional Hazard Class (IATA): NA
Packaging Group (IATA): II
UN ID Number (IATA): UN# 2024

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SECTION 15: Regulatory Information
TSCA: Not listed in the TSCA inventory.
SARA (Title 313): Title compound: See category N458 for reporting.
Second Ingredient: None

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

类别：有毒物品

• 毒性分级：剧毒
• 急性毒性（腹注-小鼠）：LD50 为 20 毫克/公斤
• 可燃性危险特性：受热分解，释放出剧毒的汞蒸气
• 储运特性：应存放在通风良好、低温干燥的库房中；与酸类、氧化剂及食品分开储存和运输

灭火剂：使用水、砂土或泡沫进行灭火

职业标准：

• 时间加权平均容许浓度（TLV-TWA）为 0.01 毫克/立方米（汞）
• 短时间暴露限值（STEL）为 0.03 毫克/立方米（汞）

反应信息

• 作为反应物：
  描述：

  甲基氢氧化汞(II) 、 2H-咪唑-2-硒酮,1,3-二氢-1,3-二甲基- 反应 360.0h， 生成
  参考文献：
  名称：

  有机omer的化学解毒

  摘要：

  包括甲基汞在内的有机汞是普遍存在的环境污染物，对人类有剧毒。现在可以证明，具有N- CH 2 CH 2 OH取代基的基于N-甲基咪唑的硫酮/硒酮对多种有机汞的解毒作用非常有效，以产生毒性较小的HgE（E = S，Se）纳米颗粒。缺少N‐ CH 2 CH 2的化合物OH取代基在用有机汞处理后无法产生HgE纳米颗粒，表明该部分通过促进脱硫和脱硒过程在脱毒中起关键作用。这种新型的有机汞解毒方法可能会导致发现治疗甲基汞中毒患者的新化合物。

  DOI：

  10.1002/anie.201504413
• 作为产物：
  描述：

  甲基汞 在 sodium hydroxide 作用下， 以 水 为溶剂， 生成 甲基氢氧化汞(II)
  参考文献：
  名称：

  Alex, Serge; Savoie, Rodrigue, Canadian Journal of Chemistry, 1987, vol. 65, p. 491 - 496

  摘要：

  DOI：
• 作为试剂：
  描述：

  间甲酚 在 乙醇 、 甲基氢氧化汞(II) 作用下， 生成 m-cresol; methylmercury m-cresolate
  参考文献：
  名称：

  Alkyl Mercury Derivatives

  摘要：

  DOI：

  10.1021/ja01327a071

文献信息

• Kinetics of extremely fast ligand-exchange reactions with methylmercury(II)-nitrothiophenolate complexes: rate-equilibria correlations
  作者：Gerhard Geier、Hugo Gross

  DOI：10.1016/s0020-1693(00)90373-6

  日期：1989.2

  S-donors can also initiate directly the ligand-exchange reactions. The rate constants for the thiophenols are always smaller than those for the thiophenolates. The reactivity of the protonated S-donors is strongly dependent on the nature of the ligand to be displaced. Several features of the reaction mechanisms involved and their relevance for the transport of CH3Hg(II) in natural systems are discussed.

  CH 3 Hg（II）从两种硝基硫代酚盐（4-硝基-2-磺基-硫代苯酚盐和4-硝基-3-羧甲基-硫代苯酚盐）转移到多种其他配体的动力学，并且已经进行了逆反应通过跳温和停流方法进行了研究。在整个平衡常数范围内，即使在等电区域，交换反应也几乎受扩散控制。质子化的S-供体也可以直接引发配体交换反应。硫酚的速率常数始终小于硫酚盐的速率常数。质子化的S-给体的反应性在很大程度上取决于要置换的配体的性质。涉及的反应机理的几个特征及其与CH 3的运输相关性讨论了自然系统中的Hg（II）。
• Complexes of 4-amino-5-mercapto-3-trifluoromethyl-1,2,4-triazole with monoorganomercury and diorganothallium derivatives. Crystal structure of dimethyl(4-amino-5-mercapto-3-trifluoromethyl-1,2,4-triazolato)thallium(III)
  作者：Y.P. Mascarenhas、I. Vencato、M.C. Carrascal、J.M. Varela、J.S. Casas、J. Sordo

  DOI：10.1016/0022-328x(88)80472-8

  日期：1988.4

  The compounds RnML (M = Hg or Tl, R = Me or Ph, n = 1 or 2 and L = 4-amino-5-mercapto-3-trifluoromethyl-1,2,4-triazolato) have been isolated. The crystal structure of the dimethylthallium(III) compound has been determined. It crystallizes in monoclinic space group P21/c, with a 11.619(1), b 8.413(1), c 11.698(4)_Å, β 108.65(2) ° and Z = 4. Refinement converged to R = 0.090 for 1103 unique observed

  已分离出化合物R n ML（M = Hg或Tl，R = Me或Ph，n = 1或2，L = 4-氨基-5-巯基-3-三氟甲基-1，2，4-三唑基）。已经确定了二甲基th（III）化合物的晶体结构。它在斜空间群结晶P 2 1 / ç，具有一个11.619（1），b 8.413（1），Ç 11.698（4）_A，β108.65（2）°和Ž = 4细化会聚到ř对于1103个唯一观察到的反射= 0.090。atom原子的配位多面体可以描述为一个非常扭曲的八面体，其赤道空位指向另一个th原子，距离为4.14。根据IR和1 H NMR数据讨论了其他化合物的结构。
• Mercury(II) and thallium(III) organometallic derivatives of 2-Mercaptobenzoxazole
  作者：M.V. Castaño、H. Calvo、A. Sánchez、J.S. Casas、J. Sordo、Y.P. Mascarenhas、C.de O.P. Santos

  DOI：10.1016/0022-328x(91)80193-n

  日期：1991.10

  its thiolic form and an almost linear CHgS linkage. Weak intramolecular and intermolecular secondary interactions complement the mercurysulphur bond. The spectroscopic (IR, Raman, mass, 13C-NMR), conductimetric, and dipolar properties of this and the other compounds are discussed.

  已经制备了一些类型为MR n L [M = Hg或Tl，R = Me或Ph且n = 1（Hg）或2（Tl）]的2-巯基苯并恶唑（HL）。HgMeL的结构已通过X射线衍射研究确定；在晶体中，每个不对称单元中都有两个独立的平面分子，其配体为巯基形式，几乎呈线性CHgS键。分子内和分子间的次要相互作用较弱，可补充汞硫键。讨论了该化合物和其他化合物的光谱（IR，拉曼光谱，质量，13 C-NMR），电导和偶极性质。
• [EN] HEAVY ATOM LABELED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACID POLYMERS, AND USES THEREOF<br/>[FR] NUCLÉOSIDES, NUCLÉOTIDES ET POLYMÈRES D'ACIDES NUCLÉIQUES MARQUÉS AVEC DES ATOMES LOURDS ET LEURS UTILISATIONS
  申请人：ZS GENETICS INC

  公开号：WO2014078652A1

  公开（公告）日：2014-05-22

  The present disclosure provides compositions and methods to sequence nucleic acid polymers for improving sequencing read length using electron microscopy, e.g., high-resolution scanning transmission electron microscopy (STEM). The present disclosure further provides heavy-atom labeled compounds of Formula (I): nucleic acid polymers comprising one or more heavy-atom labeled units of Formula (II'): such as heavy-atom labeled nucleic acid polymers of Formula (II): and salts thereof, wherein each of G 1, G2, G 3, M 1, M2, Base, and n are as defined herein, optionally for use in the methods described.

  本公开提供了一种通过电子显微镜（例如高分辨扫描透射电子显微镜（STEM））对核酸聚合物进行测序以改善测序读长的组合物和方法。本公开进一步提供了式（I）的重原子标记化合物：包括一个或多个式（II'）的重原子标记单元的核酸聚合物，例如式（II）的重原子标记核酸聚合物，以及其盐，其中G1、G2、G3、M1、M2、碱基（Base）和n的每个定义如本文所述，可选择用于所述方法中。
• The First Structurally Authenticated Organomercury(1+) Thioether Complexes − Mercury−Carbon Bond Activation Related to the Mechanism of the Bacterial Enzyme Organomercurial Lyase
  作者：Michaela Wilhelm、Stefan Deeken、Eva Berssen、Wolfgang Saak、Arne Lützen、Rainer Koch、Henry Strasdeit

  DOI：10.1002/ejic.200300907

  日期：2004.6

  methane. The degree of Hg−C bond cleavage was ca. 25% for the four-coordinate [MeHg([9]aneS3)]+ after 1 h, whereas no reaction was observed for two-coordinate [MeHg(SEt2)]+ or MeHgCl under similar conditions even after 24 h. The product Hg2+ was trapped as [Hg([9]aneS3)2]2+, which is a six-coordinate complex, as shown by a crystal structure analysis of [Hg([9]aneS3)2](BF4)2·2 CH3CN. Quantum chemical calculations

  新化合物 [MeHg([9]aneS3)](BF4) (1)、[MeHg([12]aneS3)](BF4) (2) 和 [(MeHg)2([14]aneS4)](BF4) )2 (3) 已经制备并确定了它们的晶体结构。在 1 中，硫醚充当三齿配体 [Hg-S 2.611(2)-2.768(2) A]，因此金属原子是四面体配位的，这在有机汞化学中很少见。温度相关的 1H 和 13C NMR 谱表明这种配位保留在乙腈溶液中。在晶体 2 和 3 中，线性配位的 HgII 出现，Hg-S 键长为 2.441(4) 和 2.425(2) A。发现 [MeHg([9]aneS3)]+ 对被 CF3SO3− 的配体取代是稳定的在二甲亚砜中，而硫醚部分被 CF3CO2- 取代，完全被 CH3CO2- 取代。在 [D3] 硝基甲烷中通过非常强的布朗斯台德酸 CF3SO3H 进行质子分解，将甲氨基配体转化为甲烷。Hg-C