3-氨基异噁唑-5-羧酸 | 1013-92-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 3-氨基异噁唑-5-羧酸
• 英文名称: bis(pentamethylene)thiourea
• 英文别名: N,N'-Di-pentamethylen-thioharnstoff；Di(piperidin-1-yl)methanethione
• CAS: 1013-92-9
• 化学式: C₁₁H₂₀N₂S
• 分子量: 212.359
• InChiKey: UOOSIBHMBCFJRY-UHFFFAOYSA-N

物化性质

• 熔点：
  57.5-58.5 °C
• 沸点：
  140-160 °C
• 密度：
  1.116±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  38.6
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2933399090
• 危险性防范说明：
  P261,P273,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335,H412
• 储存条件：
  | 2-8°C |

反应信息

• 作为反应物：
  描述：

  3-氨基异噁唑-5-羧酸 在 六氟磷酸钾 、 草酰氯 作用下， 以 乙腈 为溶剂， 反应 4.0h， 生成 bis(N,N-pentamethylene)chloroformamidinium hexafluorophosphate
  参考文献：
  名称：

  磷酸胍寡核苷酸新代表的合成

  摘要：

  本研究制备了磷酰胍寡核苷酸衍生物的新代表。已经提出并实施了一种合成方案，适用于从各种仲胺开始制备多种二氨基碳叠氮化物，随后通过施陶丁格反应将四取代的胍残基掺入寡核苷酸中。确定了影响磷酰基胍衍生物收率的许多因素，特别是所用叠氮化物中烷基取代基的大小、叠氮化物的纯度以及在最终脱保护之前消除保护性氰乙基的条件的寡核苷酸。

  DOI：

  10.1134/s1068162021020291
• 作为产物：
  描述：

  二环戊亚甲基二硫化四烷基秋兰姆 生成 3-氨基异噁唑-5-羧酸
  参考文献：
  名称：

  v. Braun; Anton; Weissbach, Chemische Berichte, 1930, vol. 63, p. 2847,2861

  摘要：

  DOI：

文献信息

• Steric and repeated-collision effects in diffusion-controlled reactions in solution: kinetics of formation of some iodine donor–acceptor complexes of sulphur compounds
  作者：Edward F. Caldin、L. de Forest、Alan Queen

  DOI：10.1039/ft9908601549

  日期：——

  Rates of formation of electron donor–electron acceptor complexes of iodine with some compounds of the general formula R2CS with iodine (R2CS⋯I—I) in 1-chlorobutane have been determined by means of a microwave temperature-jump apparatus. For each of these reactions, the observed forward rate constant (kf) is proportional to the theoretical diffusion-controlled value (k*D) over a range of temperatures

  已通过微波温度跳跃装置测定了碘与一些通式为R 2 CS的化合物与碘（R 2 CS = I-I）的碘的电子供体-电子受体配合物的形成速率。对于这些反应中的每一个，在一定温度范围内观察到的正向速率常数（k f）与理论扩散控制值（k * D）成正比，但略小一些。各种反应的k f / k * D值与R 2的估计表面积大致成反比CS分子。假设反应性位点的面积是恒定的，这表明ķ ˚F / ķ * d正比于分子表面面积的分数是反应性的，即该ķ ˚F是受a几何立体因素。然而，k f / k * D的观测值为。如果仅考虑具有正确方向的反应物分子之间首次碰撞的频率，则该分子比基于该模型的分子模型所预期的分子大小大四倍。可以通过考虑以下事实来消除这种差异：在相遇过程中反复发生碰撞会增加成功碰撞的机会。具有有限反应位点的分子之间相遇的硬球模型，通过碰撞之间的旋转而重新定向，这表明重复的碰撞可能会导致k f / k
• Palladium‐Catalyzed Desulfurative Amide Formation from Thioureas and Arylboronic Acids
  作者：Jianke Su、Wendong Li、Xin Li、Jian Xu、Qiuling Song

  DOI：10.1002/cctc.202001099

  日期：2020.11.19

  Pd‐catalyzed desulfurative amide formation involved Suzuki‐Miyaura coupling reaction, notably the Pd complex was generated in situ from thioureas, Ag salt and Pd catalyst. Silver salt was essential for the construction of this type of carbenes from available and stable thioureas and well participated in the catalytic cycle. We report a method for the synthesis of arylamides from arylboronic acids, which

  卡宾配合物的反应性的发展将导致创建新的合成策略。我们在本文中发现Pd催化的脱硫酰胺形成涉及Suzuki-Miyaura偶联反应，特别是Pd配合物是由硫脲，Ag盐和Pd催化剂原位生成的。银盐对于从可用的和稳定的硫脲构建此类卡宾是必不可少的，并且很好地参与了催化循环。我们报道了一种由芳基硼酸合成芳基酰胺的方法，该方法极大地丰富了硫脲化学的应用并扩展了Suzuki-Miyaura偶联的应用。
• FUNCTIONALIZED HIGHLY BRANCHED MELAMINE-POLYAMINE POLYMERS
  申请人：Peretolchin Maxim

  公开号：US20120252987A1

  公开（公告）日：2012-10-04

  The present invention relates to a method for producing amphiphilic functionalized highly branched melamine-polyamine polymers by condensing melamine and optionally a melamine derivate having at least one different amine having at least two primary amino groups and optionally also with urea and/or at least one urea derivative and/or with at least one at least difunctional diisocyanate or polyisocyanate and/or at least one carbolic acid having at least two carboxyl groups or at least one derivative thereof, optionally quaternizing a portion of the amino groups of the polymer thereby obtained, reacting the polymer thus obtained with at least one compound capable of undergoing a condensation or addition reaction with amino groups, and optionally quaternizing at least part of the amino groups of the polymer obtained in the first step. The invention further relates to the amphiphilic functionalized highly branched melamine-polyamine polymers that can be obtained by the method according to the invention, and to the use thereof as surface active agents.

  本发明涉及一种通过将三聚氰胺和至少一种具有至少两个主要氨基的不同氨基的三聚氰胺衍生物以及可能还包括尿素和/或至少一种尿素衍生物和/或至少一种至少双官能团二异氰酸酯或多异氰酸酯和/或至少一种至少具有两个羧基的羧酸或其衍生物缩合，从而制备含有两性功能化的高支化三聚氰胺-多胺聚合物的方法。可选地，对所获得的聚合物的部分氨基进行季铵化，然后将所获得的聚合物与至少一种能够与氨基发生缩合或加成反应的化合物反应，并可选地对第一步中获得的聚合物的部分氨基进行季铵化。本发明还涉及通过本发明的方法可以获得的含有两性功能化的高支化三聚氰胺-多胺聚合物，以及将其用作表面活性剂的用途。
• Heterocyclic fused imidazolone, dioxolone, imidazolethione and dioxolethione monomers
  申请人：Zahn Steffen

  公开号：US20070282099A1

  公开（公告）日：2007-12-06

  A method of making a compound of the formula shown below is disclosed: wherein Z is Se or S; Y is NH or O; X is O or S and W and W′ are independently selected from the group consisting of hydrogen, —C═ONH 2 , —C═ONHR′, —C═ONR′R′, —C≡N, and R′ is C 1-6 alkyl and the resultant monomer compounds. The method includes contacting a 3,4-disubstituted thiophene or selenophene or disubstituted thiophene or selenophene derivatives with a carbonyl or thiocarbonyl containing compound selected from the group consisting of ureas, thioureas, carbonate esters, thionocarbonates, thiocarbonate esters, or orthocarbonates. The monomer compounds are suitable for forming polymers for use in a wide range of electronic applications.

  揭示了一种制备如下式化合物的方法：其中Z为Se或S；Y为NH或O；X为O或S，W和W′从羟基，-C═ONH2，-C═ONHR′，-C═ONR′R′，-C≡N和R′为C1-6烷基的组中独立选择，以及所得的单体化合物。该方法包括将3,4-二取代噻吩或硒吩或二取代噻吩或硒吩衍生物与含有羰基或硫代羰基的化合物接触，所述化合物从尿素，硫脲，碳酸酯，硫代碳酸酯，硫代碳酸酯酯或正碳酸酯中选择。单体化合物适用于形成聚合物，用于各种电子应用。
• Overbased sulfurized alkyl-phenols as lubricating oil additives
  申请人：CHEVRON RESEARCH AND TECHNOLOGY COMPANY

  公开号：EP0259974A2

  公开（公告）日：1988-03-16

  Oil-soluble hydrolytically stable Group II metal overbased sulfurized alkylphenol reaction products are characterized as possessing a Total Base Number of at least 300 and a viscosity of not more than 800 centistokes at 100°C and containing less than 10 mole percent of unsulfurized Group II metal alkylphenol in the actives. These reaction products, which are useful as lubricating oil additives, are obtained by a process in which the appropriate reactants are reacted together in the presence of a sulfurization catalyst which enables reaction products of such high Total Base Numbers and low viscosities to be obtained.

  油溶性水解稳定的 II 族金属过基硫化烷基酚反应产物的特点是，总碱基数至少为 300，100°C 时粘度不超过 800 厘沲，并且活性物中未硫化 II 族金属烷基酚的含量低于 10 摩尔%。 这些可用作润滑油添加剂的反应产物是通过以下工艺获得的：在硫化催化剂存在下，适当的反应物一起反应，从而获得高总碱基数和低粘度的反应产物。