12'-iodovinblastine 、
乙硫醇钠 在
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 作用下,
以
N,N-二甲基甲酰胺 为溶剂,
生成 methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15S,17S)-17-ethyl-7-ethylsulfanyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5(10),6,8-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate