(2S)-2-phenyl-1-propan-2-ylpiperazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (2S)-2-phenyl-1-propan-2-ylpiperazine
• 化学式: C₁₃H₂₀N₂
• 分子量: 204.31
• InChiKey: QNEDUVPWULUDID-CYBMUJFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] BICYCLIC BET BROMODOMAIN INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE BROMODOMAINES BET BICYCLIQUES ET LEURS UTILISATIONS
  申请人：STROVEL JEFFREY WILLIAM

  公开号：WO2017091661A1

  公开（公告）日：2017-06-01

  The present invention relates to compounds that bind to and otherwise modulate the activity of bromodomain-containing proteins, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders.

  本发明涉及结合并调节含有溴结构域蛋白的化合物，制备这些化合物的方法，含有这些化合物的药物组合物，以及使用这些化合物治疗各种疾病和疾病的方法。
• Small molecule BET bromodomain inhibitors and uses thereof
  申请人：ConverGene LLC

  公开号：US11028079B2

  公开（公告）日：2021-06-08

  The present invention relates to compounds that bind to and otherwise modulate the activity of bromodomain-containing proteins, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders.

  本发明涉及与含溴结构域蛋白质结合或以其他方式调节其活性的化合物、制备这些化合物的工艺、含有这些化合物的药物组合物，以及使用这些化合物治疗各种病症和疾病的方法。
• SMALL MOLECULE BET BROMODOMAIN INHIBITORS AND USES THEREOF
  申请人：ConverGene LLC

  公开号：US20200223836A1

  公开（公告）日：2020-07-16

  The present invention relates to compounds that bind to and otherwise modulate the activity of bromodomain-containing proteins, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders.