2-[4-(2-methoxyphenyl)piperazin-1-yl]-4H-quinolin-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-[4-(2-methoxyphenyl)piperazin-1-yl]-4H-quinolin-3-one
• 化学式: C₂₀H₂₁N₃O₂
• 分子量: 335.4
• InChiKey: ITNRKRAPXKWUAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  45.1
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Efficient delivery of therapeutic molecules to cells of the inner ear
  申请人：Massachusetts Eye and Ear Infirmary

  公开号：US11370823B2

  公开（公告）日：2022-06-28

  Compositions and provided to induce cells of the inner ear to renter the cell cycle and to proliferate. In particular, hair cells are induced to proliferate by administration of a composition which activates the Myc and Notch. Supporting cells are induced to transdifferentiate to hair cells by inhibition of Myc and Notch activity or the activation of Atoh1. Methods of treatment include the intracellular delivery of these molecules to a specific therapeutic target.

  提供了诱导内耳细胞进入细胞周期和增殖的组合物。特别是，通过服用能激活 Myc 和 Notch 的组合物来诱导毛细胞增殖。通过抑制 Myc 和 Notch 的活性或激活 Atoh1，诱导支持细胞向毛细胞转分化。治疗方法包括在细胞内将这些分子输送到特定的治疗靶点。
• METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS AND/OR SUPPORTING CELLS
  申请人：Massachusetts Eye & Ear Infirmary

  公开号：EP2892523B1

  公开（公告）日：2019-05-01
• EFFICIENT DELIVERY OF THERAPEUTIC MOLECULES TO CELLS OF THE INNER EAR
  申请人：Massachusetts Eye and Ear Infirmary

  公开号：EP3212773B1

  公开（公告）日：2021-09-15
• TREATMENT OF HEARING LOSS
  申请人：Massachusetts Eye & Ear Infirmary

  公开号：EP3743057A1

  公开（公告）日：2020-12-02
• [EN] METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS AND/OR SUPPORTING CELLS<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR LA RÉGÉNÉRATION DE CELLULES CAPILLAIRES ET/OU DE CELLULES AUXILIAIRES
  申请人：MASSACHUSETTS EYE & EAR INFIRM

  公开号：WO2014039908A1

  公开（公告）日：2014-03-13

  Provided are methods and compositions for inducing cells of the inner ear (for example, cochlear and utricular hair cells) to reenter to cell cycle and to proliferate. More particularly, the invention relates to the use of agents that increase c-myc activity and/or Notch activity for inducing cell cycle reentry and proliferation of cochlear or utricular hair cells and/or cochlear or utricular supporting cells. The methods and compositions can be used to promote the proliferation of hair cells and/or supporting cells to treat a subject at risk of, or affected with, hearing loss or a subject at risk of, or affected with vestibular dysfunction.