Tert-butyl 4-[2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]ethyl]piperazine-1-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: Tert-butyl 4-[2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]ethyl]piperazine-1-carboxylate
• 英文别名: tert-butyl 4-[2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]ethyl]piperazine-1-carboxylate
• 化学式: C₂₁H₃₄N₄O₅
• 分子量: 422.5
• InChiKey: XVAGSOIZMPXJQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  30
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  99.3
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• AMATOXIN DERIVATIVES AND CELL-PERMEABLE CONJUGATES THEREOF AS INHIBITORS OF RNA POLYMERASE
  申请人：MENDELSOHN Brian Alan

  公开号：US20150218220A1

  公开（公告）日：2015-08-06

  The present invention relates to analogs of alpha-amanitin, methods of inhibiting RNA polymerase with such compounds, conjugates comprising such compounds, compositions comprising such compounds and conjugates, and methods of treatment using such conjugates.
• [EN] AMATOXIN DERIVATIVES AND CELL-PERMEABLE CONJUGATES THEREOF AS INHIBITORS OF RNA POLYMERASE<br/>[FR] DÉRIVÉS D'AMATOXINE ET CONJUGUÉS À BASE DE CEUX-CI, À PERMÉABILITÉ CELLULAIRE, EN TANT QU'INHIBITEURS DE L'ARN POLYMÉRASE
  申请人：AGENSYS INC

  公开号：WO2014043403A1

  公开（公告）日：2014-03-20

  The present invention relates to analogs of alpha-amanitin, methods of inhibiting RNA polymerase with such compounds, conjugates comprising such compounds, compositions comprising such compounds and conjugates, and methods of treatment using such conjugates.