3-(4-Methylpiperazin-1-yl)-3-oxopropanimidamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 3-(4-Methylpiperazin-1-yl)-3-oxopropanimidamide
• 英文别名: 3-(4-methylpiperazin-1-yl)-3-oxopropanimidamide
• 化学式: C₈H₁₆N₄O
• 分子量: 184.24
• InChiKey: WJYNNZJVOKYANR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  73.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• MATRIPTASE INHIBITORS AND USES THEREOF AGAINST ORTHOMYXOVIRIDAE INFECTIONS
  申请人：Richter Martin

  公开号：US20140086936A1

  公开（公告）日：2014-03-27

  The present invention provides matriptase inhibitors and compositions for treating and preventing orthomyxovirus infections such as flu infections. The present invention also provides novel compounds, compositions, methods of use, uses and kits thereof for inhibiting matriptase. Such compounds are useful for treating and preventing orthomyxovirus infections, such as flu infections, and for inhibiting tumor growth, progression and/or metastasis.