5-(2-Chloro-phenyl)-7-ethyl-1-methyl-2,3-dihydro-1H-thieno[2,3-e][1,4]diazepine | 77959-53-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻烯杂卓类
• 英文名称: 5-(2-Chloro-phenyl)-7-ethyl-1-methyl-2,3-dihydro-1H-thieno[2,3-e][1,4]diazepine
• 英文别名: 5-(2-Chlorophenyl)-7-ethyl-1-methyl-2,3-dihydrothieno[2,3-e][1,4]diazepine；5-(2-chlorophenyl)-7-ethyl-1-methyl-2,3-dihydrothieno[2,3-e][1,4]diazepine
• CAS: 77959-53-6
• 化学式: C₁₆H₁₇ClN₂S
• 分子量: 304.843
• InChiKey: UJYCEOSEYONDCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  43.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• ORAL DRUG DELIVERY FORMULATIONS
  申请人：Odidi, Isa

  公开号：EP2906202A1

  公开（公告）日：2015-08-19
• COMPOSITIONS AND METHODS FOR REDUCING OVERDOSE
  申请人：Odidi, Isa

  公开号：EP3169316A1

  公开（公告）日：2017-05-24
• [EN] ORAL DRUG DELIVERY FORMULATIONS<br/>[FR] FORMULATIONS DE MÉDICAMENT POUR ADMINISTRATION PAR VOIE ORALE
  申请人：ODIDI ISA

  公开号：WO2014059512A1

  公开（公告）日：2014-04-24

  In an aspect, a formulation is provided that comprises at least one active substance and at least one coat comprising Eudragit E (dimethylaminoethyl methacrylate copolymer), wherein the formulation is free of any active substance external to the coat. The formulation is effective in preventing significant dose dumping in alcoholic/non-alcoholic beverage(s). In another aspect, a formulation is provided that comprises a loading dose having at least one active substance, wherein the release of the at least one active substance shows a Point Of Divergence (POD), in a dissolution profile, with the loading dose representing a point in a timeline where the history of the dissolution or release rate changes from an onset of action to another set of points in the timeline represented by a controlled release. The formulation may be used for releasing up to about 55% of a total dose as a loading dose in order to manage pain.
• [EN] COMPOSITIONS AND METHODS FOR REDUCING OVERDOSE<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR RÉDUIRE UNE SURDOSE
  申请人：ODIDI ISA

  公开号：WO2016023108A1

  公开（公告）日：2016-02-18

  Drug delivery formulations useful to prevent or reduce purposeful or accidental overdose of a drug, and methods of making the same are provided. The formulations comprise either an alkalinizing coat in an amount sufficient to raise the pH of the stomach, or an acidifying coat in an amount sufficient to lower the pH of the duodenum, such that dissolution of an underlying acid or base labile coat is inhibited when excess dosage forms are ingested, thereby reducing or inhibiting the release of the drug contained therein.
• [EN] IMPROVED COMPOSITIONS AND METHODS FOR REDUCING OVERDOSE<br/>[FR] COMPOSITIONS AMÉLIORÉES ET PROCÉDÉS POUR RÉDUIRE UNE SURDOSE
  申请人：ODIDI ISA

  公开号：WO2018137018A1

  公开（公告）日：2018-08-02

  Improved drug delivery formulations, uses thereof and methods of making same are provided in order to reduce the potential for abuse, misuse or improper administration of an addictive substance or any active substance and to prevent, reduce, inhibit, or delay purposeful or accidental overdose of an active substance by ingesting too many dosage forms at once, for example.