3-Acetyl-1-cyclopentyl-4-methyl-7-[(5-piperazin-1-ylpyridin-2-yl)amino]quinolin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 3-Acetyl-1-cyclopentyl-4-methyl-7-[(5-piperazin-1-ylpyridin-2-yl)amino]quinolin-2-one
• 英文别名: 3-acetyl-1-cyclopentyl-4-methyl-7-[(5-piperazin-1-ylpyridin-2-yl)amino]quinolin-2-one
• 化学式: C₂₆H₃₁N₅O₂
• 分子量: 445.6
• InChiKey: FUIRZSBOHWRXEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  77.6
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• BLOCK COPOLYMERS FOR STABLE MICELLES
  申请人：Intezyne Technologies, Inc.

  公开号：US20140113879A1

  公开（公告）日：2014-04-24

  The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same. Compositions herein are useful for drug-delivery applications.
• IRON STABILIZED MICELLES AS MAGNETIC CONTRAST AGENTS
  申请人：Intezyne Technologies

  公开号：US20160346408A1

  公开（公告）日：2016-12-01

  The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and iron stabilized micelles comprising the same, as magnetic contrast agents. Compositions herein are useful for diagnostic and drug-delivery applications.
• INDOLE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS
  申请人：Arvinas Operations, Inc.

  公开号：US20210040081A1

  公开（公告）日：2021-02-11

  The present disclosure relates to compounds and a pharmaceutically acceptable salt thereof, compositions, combinations and medicaments containing the compounds, and processes for their preparation. The disclosure also relates to the use of the compounds, combinations, compositions and medicaments, for example as inhibitors of the activity of the estrogen receptor, including degrading the estrogen receptor, the treatment of diseases and conditions mediated by the estrogen receptor.
• US9944752B2
  申请人：——

  公开号：US9944752B2

  公开（公告）日：2018-04-17