2-[4-[9-Cyclopentyl-6-[(4-thiophen-3-ylphenyl)methylamino]purin-2-yl]piperazin-1-yl]ethanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-[4-[9-Cyclopentyl-6-[(4-thiophen-3-ylphenyl)methylamino]purin-2-yl]piperazin-1-yl]ethanol
• 英文别名: 2-[4-[9-cyclopentyl-6-[(4-thiophen-3-ylphenyl)methylamino]purin-2-yl]piperazin-1-yl]ethanol
• 化学式: C₂₇H₃₃N₇OS
• 分子量: 503.7
• InChiKey: AVHNPAOSQFQNHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  111
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• 2-SUBSTITUTED-6-BIARYLMETHYLAMINO-9-CYCLOPENTYL-9H-PURINE DERIVATIVES, USE THEREOF AS MEDICAMENTS, AND PHARMACEUTICAL COMPOSITIONS
  申请人：UNIVERZITA PALACKEHO V OLOMOUCI

  公开号：US20150368248A1

  公开（公告）日：2015-12-24

  This invention relates to novel 2-substituted-6-biarylmethylamino-9-cyclopentyl-9H-purine derivatives, showing activity as specific inhibitors of growth and angiogenesis of hepatocellular carcinoma. The invention further includes pharmaceutical compositions containing the 2-substituted-6-biarylmethylamino-9-cyclopentylpurines.

  本发明涉及新颖的2-取代-6-双芳基甲氨基-9-环戊基-9H-嘌呤衍生物，显示出作为肝细胞癌生长和血管生成特异性抑制剂的活性。本发明进一步包括含有这些2-取代-6-双芳基甲氨基-9-环戊基嘌呤的药物组合物。
• [EN] 2-SUBSTITUTED-6-BIARYLMETHYLAMINO-9-CYCLOPENTYL-9H-PURINE DERIVATIVES, USE THEREOF AS MEDICAMENTS, AND PHARMACEUTICAL COMPOSITIONS<br/>[FR] DÉRIVÉS DE 6-BIARYLMÉTHYLAMINO-9-CYCLOPENTYL-9H-PURINE 2-SUBSTITUÉE, LEUR UTILISATION COMME MÉDICAMENTS ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：UNIV PALACKEHO

  公开号：WO2014121764A2

  公开（公告）日：2014-08-14

  This invention relates to novel 2-substituted-6-biarylmethylamino-9-cyclopentyl-9H-purine derivatives, showing activity as specific inhibitors of growth and angiogenesis of hepatocellular carcinoma. The invention further includes pharmaceutical compositions containing the 2-substituted-6-biarylmethylamino-9-cyclopentylpurines.