2-[2-Ethoxy-4-[4-(4-propan-2-yloxyphenyl)sulfonylpiperazin-1-yl]phenyl]-1,3-oxazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-[2-Ethoxy-4-[4-(4-propan-2-yloxyphenyl)sulfonylpiperazin-1-yl]phenyl]-1,3-oxazole
• 英文别名: 2-[2-ethoxy-4-[4-(4-propan-2-yloxyphenyl)sulfonylpiperazin-1-yl]phenyl]-1,3-oxazole
• 化学式: C₂₄H₂₉N₃O₅S
• 分子量: 471.6
• InChiKey: LZEUCALCJGJJCO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  93.5
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• DRUG FOR THE TREATMENT OF ALLERGIC RHINITIS COMPRISING PGD2 ANTAGONIST AND HISTAMINE ANTAGONIST
  申请人：Shionogi & Co., Ltd.

  公开号：US20140243351A1

  公开（公告）日：2014-08-28

  A medicament for treating allergic rhinitis, characterized in that (A) a compound represented by the formula (I) or a pharmaceutically acceptable salt thereof, is combined with (B) at least one compound selected from the group consisting of cetirizine, fexofenadine, and loratadine, or a pharmaceutically acceptable salt thereof. Since the effects of the medicament for treating allergic rhinitis of the present invention surpass the sum of the effects of single dose of each of the agents against the allergic rhinitis, the medicament is useful as a medicament for treating allergic rhinitis having potent effects.
• US9440938B2
  申请人：——

  公开号：US9440938B2

  公开（公告）日：2016-09-13