6-methyl-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine 1,1-dioxide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻二嗪
• 英文名称: 6-methyl-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine 1,1-dioxide
• 英文别名: 6-methyl-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine 1,1-dioxide
• 化学式: C₈H₁₀N₂O₂S
• 分子量: 198.24
• InChiKey: NJCNGGAXJJGPBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  66.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Indole derivative used as CRTH2 inhibitor
  申请人：CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

  公开号：US10800765B2

  公开（公告）日：2020-10-13

  The present application discloses an indole as represented by formula (I) used as a CRTH2 inhibitor, and a pharmaceutically acceptable salt or tautomer of the indole, and an application of same in treating a disease related to a CRTH2 receptor.

  本申请公开了一种由式（I）表示的用作 CRTH2 抑制剂的吲哚、该吲哚的药学上可接受的盐或同系物，以及其在治疗与 CRTH2 受体有关的疾病中的应用。
• DIPEPTIDE ANALOGS AS COAGULATION FACTOR INHIBITORS
  申请人：Bristol-Myers Squibb Company

  公开号：EP2152664B1

  公开（公告）日：2014-09-03
• INDOLE DERIVATIVE USED AS CRTH2 INHIBITOR
  申请人：CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

  公开号：US20190248770A1

  公开（公告）日：2019-08-15

  The present application discloses an indole as represented by formula (I) used as a CRTH2 inhibitor, and a pharmaceutically acceptable salt or tautomer of the indole, and an application of same in treating a disease related to a CRTH2 receptor.