3-(4-Fluoronaphthalen-1-yl)-3-[4-[4-nitro-2-(trifluoromethyl)phenyl]piperazin-1-yl]propan-1-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 3-(4-Fluoronaphthalen-1-yl)-3-[4-[4-nitro-2-(trifluoromethyl)phenyl]piperazin-1-yl]propan-1-ol
• 英文别名: 3-(4-fluoronaphthalen-1-yl)-3-[4-[4-nitro-2-(trifluoromethyl)phenyl]piperazin-1-yl]propan-1-ol
• 化学式: C24H23F4N3O3
• 分子量: 477.5
• InChiKey: DBACEXPVXZUTBU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  72.5
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• [EN] NEW ARYLAMINOALCOHOL DERIVATIVES WITH ANTIPLASMODIAL ACTIVITY<br/>[FR] NOUVEAUX DÉRIVÉS ARYL-AMINO-ALCOOL À ACTIVITÉ ANTIPLASMODIQUE
  申请人：INST RECH DEVELOPPEMENT IRD

  公开号：WO2014140671A1

  公开（公告）日：2014-09-18

  The present invention relates to new arylaminoalcohol derivatives of formula (I), and to a method for the preparation of such compounds: The invention also relates to the use of these compounds as medicaments, and in particular for the prevention and/or the treatment of parasitic diseases caused by apicomplexan parasites such as malaria and toxoplasmosis. Finally, the invention relates to pharmaceutical compositions containing such compounds of formula (I) as active principles.