1-(2-Chloroethyl)-3-(1-methoxypropan-2-yl)urea

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: 1-(2-Chloroethyl)-3-(1-methoxypropan-2-yl)urea
• 英文别名: 1-(2-chloroethyl)-3-(1-methoxypropan-2-yl)urea
• 化学式: C₇H₁₅ClN₂O₂
• 分子量: 194.66
• InChiKey: VEKNTDNDGFYPHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  50.4
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• IMIDAZOLIDINONES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES
  申请人：Deciphera Pharmaceuticals, LLC

  公开号：US20140315917A1

  公开（公告）日：2014-10-23

  Described are compounds of Formula I which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-1R), c-KIT, and/or PDGFR kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c-FMS, c-KIT, or PDGFR kinases.

  描述了一种化合物，其化学式为I，通过抑制c-FMS（CSF-1R）、c-KIT和/或PDGFR激酶，在治疗癌症、自身免疫疾病和代谢性骨疾病方面具有用途。这些化合物还在治疗其他由c-FMS、c-KIT或PDGFR激酶介导的哺乳动物疾病中发挥作用。
• US9133183B2
  申请人：——

  公开号：US9133183B2

  公开（公告）日：2015-09-15
• [EN] IMIDAZOLIDINONES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES<br/>[FR] IMIDAZOLIDINONES ET ANALOGUES À ACTIVITÉS ANTI-CANCER ET ANTI-PROLIFÉRATION
  申请人：DECIPHERA PHARMACEUTICALS LLC

  公开号：WO2014145015A2

  公开（公告）日：2014-09-18

  Described are compounds of Formula I which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-IR), c-KIT, and/or PDGFR kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c- FMS, c-KIT, or PDGFR kinases.