N-甲氧基氨基甲酸乙酯 | 3871-28-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 中文名称: N-甲氧基氨基甲酸乙酯
• 英文名称: ethyl N-methoxycarbamate
• CAS: 3871-28-1
• 化学式: C₄H₉NO₃
• mdl: MFCD00624200
• 分子量: 119.12
• InChiKey: YBURKGRQNJPCSW-UHFFFAOYSA-N

物化性质

• 沸点：
  50°/0.5mm

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2924199090

反应信息

• 作为反应物：
  描述：

  N-甲氧基氨基甲酸乙酯 在 silver(l) oxide 作用下， 以 乙醚 为溶剂， 生成 N,N'-bis(ethoxycarbonyl)-N,N'-dimethoxyhydrazine
  参考文献：
  名称：

  The Synthesis and Reactions of N,N'-Dicarbalkoxy-N,N'-dialkoxyhydrazines and Some Observations on Carbalkoxylium Ions

  摘要：

  DOI：

  10.1021/jo01044a066
• 作为产物：
  描述：

  N-羟基氨基甲酸乙酯 、 硫酸二甲酯 在 氢氧化钾 作用下， 生成 N-甲氧基氨基甲酸乙酯
  参考文献：
  名称：

  Major; Fleck, Journal of the American Chemical Society, 1928, vol. 50, p. 1480

  摘要：

  DOI：

文献信息

• The synthesis and some reactions of N-hydroxycarbamates
  作者：E. Boyland、R. Nery

  DOI：10.1039/j39660000346

  日期：——

  chloroformate, gave N-hydroxy-N-phenylurethane. Hydroxylamine hydrochloride and ethyl chloroformate yielded a product which changed into hydroxyurethane. Alkyl N-hydroxycarbamates and hydroxyurea gave O-xanthydryl derivatives. The N-hydroxycarbamates with aqueous dipotassium tetracyanonickelate(II) formed dipotassium tricyanonitrosylnickelate(II). No evidence of a Lossen-type rearrangement during the acid

  羟胺和氯甲酸烷基酯在碱性介质中反应，以形成ñ - ， - NO -二- ，和NNO -三烷氧羰基羟胺，依次。N-甲基羟胺类似地得到N-和NO-二烷氧基羰基-N-甲基-羟胺，O-甲基羟胺产生N-和NN-二烷氧基羰基-O-甲基羟胺。N-苯基羟胺与1当量的氯甲酸乙酯反应，得到N-羟基-N-苯基氨基甲酸酯。盐酸羟胺和氯甲酸乙酯产生产物，其变为羟基氨基甲酸酯。N-羟基氨基甲酸酯烷基和羟基脲得到O-黄羟基衍生物。所述Ñ -hydroxycarbamates用含水四氰二钾（II）而形成二钾tricyanonitrosylnickelate（II）。在这些羟氨基衍生物的酸和碱水解过程中，没有证据表明发生了洛森型重排。讨论了可能的水解机理。
• ORGANIC COMPOUNDS
  申请人：Baettig Urs

  公开号：US20100029670A1

  公开（公告）日：2010-02-04

  The present invention relates to compounds of formula (I) wherein X, R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein, which are useful for treating diseases which respond to CXCR2 receptor mediators. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

  本发明涉及以下式（I）的化合物 其中X，R1，R2，R3，R4和R5如本文所定义，这些化合物对于治疗对CXCR2受体介质有响应的疾病是有用的。还描述了含有这些化合物的药物组合物以及制备这些化合物的方法。
• Reactions of hydroxylamines with ethyl cyanoformate. preparation of aminonitrones and their synthetic applications.
  作者：Paula S. Branco、Sundaresan Prabhakar、Ana M. Lobo、David J. Williams

  DOI：10.1016/s0040-4020(01)88224-7

  日期：1992.1

  The reaction of hydroxylamines with ethyl cyanoformate leads to the formation of carbethoxyamino nitrones . UV spectroscopy provided information that suggested the nitrone structure for these compounds in solution. X-ray analysis of confirmed that it exists entirely in the nitrone form in the solid state. These nitrones are shown to be excellent starting materials for a variety of nitrogen containg

  羟胺与氰基甲酸乙酯的反应导致形成乙氧基氨基硝酮。紫外光谱提供的信息表明溶液中这些化合物的硝酮结构。的X射线分析证实其完全以固态存在于硝酮形式。这些硝酮被证明是各种含氮化合物（即咪唑，苯并咪唑，苯并咪唑酮，恶二唑酮，N-芳基idine啶和喹喔啉）的极佳原料。
• Geminal systems
  作者：V. G. Shtamburg、R. G. Kostyanovsky、A. V. Tsygankov、V. V. Shtamburg、O. V. Shishkin、R. I. Zubatyuk、A. V. Mazepa、S. V. Kravchenko

  DOI：10.1007/s11172-015-0822-9

  日期：2015.1

  Molecular and crystal structures of N-alkoxy-N-chloroureas and N,N-dialkoxyureas were studied together with those of N-alkoxyureas as reference compounds. N-Alkoxy-N-chloroureas were found to have an elongated N—Cl bond and a shortened N–O(Alk) bond due to the nO(Alk)→σ*N–Cl anomeric effect. Alcoholysis of N-alkoxy-N-chloro derivatives of urea, N′-arylureas, and carbamates in the presence of silver trifluoroacetate leads to sterically hindered N,N-dialkoxyureas, N,N-dialkoxy-N′-arylureas, and N,N-dialkoxycarbamates, respectively.

  研究了N-烷氧基-N-氯脲和N,N-二烷氧基脲的分子和晶体结构，同时以N-烷氧基脲作为参考化合物。发现N-烷氧基-N-氯脲具有拉长的N—Cl键和缩短的N–O(Alk)键，这归因于nO(Alk)→σ*N–Cl的异构效应。在三氟乙酸银存在下，对N-烷氧基-N-氯衍生物、N′-芳基脲和氨基甲酸酯的醇解反应分别得到空间位阻较大的N,N-二烷氧基脲、N,N-二烷氧基-N′-芳基脲和N,N-二烷氧基氨基甲酸酯。
• Mg^II -Catalyzed Desymmetrization Reaction of <i>meso</i> -Aziridines with Hydroxylamines: Synthesis of Novel Chiral 1,2-Diamine Skeletons
  作者：Dan Li、Dongxu Yang、Linqing Wang、Xihong Liu、Xianxing Jiang、Rui Wang

  DOI：10.1002/chem.201603898

  日期：2016.11.21

  for the first time. A series of novel chiral 1,2‐diamine skeletons were obtained in good yields and enantioselectivities. The reaction employed magnesium catalysis generated in situ from a simple oxazoline‐OH chiral ligand. Obviously, the diverse structures of the obtained chiral 1,2‐diamine compounds could allow them to be potential chiral ligands in future catalytic asymmetric synthesis studies.

  首次公开了Mg II催化的内消旋氮丙啶与羟胺的脱对称反应。以良好的收率和对映选择性获得了一系列新颖的手性1,2-二胺骨架。该反应采用由简单的恶唑啉-OH手性配体原位生成的镁催化。显然，获得的手性1,2-二胺化合物的不同结构可能使它们成为未来催化不对称合成研究中潜在的手性配体。