(3E)-3-[[2-(4-methylpiperazin-1-yl)phenyl]methylidene]-1H-indol-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (3E)-3-[[2-(4-methylpiperazin-1-yl)phenyl]methylidene]-1H-indol-2-one
• 化学式: C₂₀H₂₁N₃O
• 分子量: 319.4
• InChiKey: GVZDDZHOCZYDBT-SAPNQHFASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  35.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Phenoxypropylamine compounds
  申请人：——

  公开号：US20020111358A1

  公开（公告）日：2002-08-15

  The present invention relates to a phenoxypropylamine compound of the formula (I) 1 wherein each symbol is as defined in the specification, an optically active compound thereof or a pharmaceutically acceptable salt thereof and hydrates thereof, which simultaneously show selective affinity for and antagonistic activity against 5-HT 1A receptor, as well as 5-HT reuptake inhibitory activity, and can be used as antidepressants quick in expressing an anti-depressive effect.

  本发明涉及一种公式（I）中的苯氧丙胺化合物： 1 其中每个符号如说明书中所定义，其光学活性化合物或其药物可接受的盐及水合物，同时显示出对5-HT 1A 受体的选择性亲和力和拮抗活性，以及5-HT再摄取抑制活性，并且可以用作快速表达抗抑郁效果的抗抑郁药。
• Benzyl(idene)-lactam derivatives, their preperation and their use as selective (ant)agonists of 5-HT1A- and/or 5-HT1D receptors
  申请人：Pfizer Inc.

  公开号：US20030027812A1

  公开（公告）日：2003-02-06

  The present invention relates to lactam derivatives of the formula 1 wherein R 1 , R 2 , R 3 , A, X, Z, n and the dashed line are defined herein, and pharmaceutical compositions thereof, to processes and intermediates for their preparation, and to their medicinal use as selective agonists and antagonists of serotonin 1 (5-HT 1 ) receptors, specifically, of one or both of the 5-HT 1A and 5-HT 1D receptors. These compounds are useful in treating or preventing migraine, depression and other disorders for which a 5-HT 1 agonist or antagonist is indicated.

  本发明涉及公式1的内酰胺衍生物，其中R1、R2、R3、A、X、Z、n和虚线在此被定义，以及其药物组成物、制备过程和中间体，以及它们作为选择性5-羟色胺1（5-HT1）受体的激动剂和拮抗剂的药用。具体来说，是对5-HT1A和5-HT1D受体中的一个或两个的选择性拮抗剂和激动剂。这些化合物在治疗或预防偏头痛、抑郁症和其他需要5-HT1激动剂或拮抗剂的疾病中非常有用。
• PHENOXYPROPYLAMINE COMPOUNDS
  申请人：Mitsubishi Pharma Corporation

  公开号：EP1188747B1

  公开（公告）日：2005-09-07
• BENZYL(IDENE)-LACTAM DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE (ANT)AGONISTS OF 5-HT1A- AND/OR 5-HT1D RECEPTORS
  申请人：PFIZER INC.

  公开号：EP0894085A1

  公开（公告）日：1999-02-03
• US6462048B2
  申请人：——

  公开号：US6462048B2

  公开（公告）日：2002-10-08