(Z)-(5-Bromo-2-thienyl)ethanone oxime

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: (Z)-(5-Bromo-2-thienyl)ethanone oxime
• 英文别名: (NE)-N-[1-(5-bromothiophen-2-yl)ethylidene]hydroxylamine
• 化学式: C₆H₆BrNOS
• 分子量: 220.09
• InChiKey: GGNDYUAZNCRVDC-XBXARRHUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  60.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (Z)-(5-Bromo-2-thienyl)ethanone oxime 、 五氯化磷 以74%的产率得到
  参考文献：
  名称：

  METH-COHN O.; NARINE B., SYNTHESIS, 1980, NO 2, 133-135

  摘要：

  DOI：
• 作为产物：
  描述：

  2-乙酰基-5-溴噻吩 、 羟胺 以71%的产率得到
  参考文献：
  名称：

  ZEMTSOVA, M. N.;TRAXTENBERG, P. L.;KALININA, M. N.;GOLOVANOVA, T. YU.;ZUD+, XIMIYA I TEXNOL. EHLEMENTOORGAN. POLUPRODUKTOV I POLIMEROV, VOLGOGRAD, 19+

  摘要：

  DOI：

文献信息

• [EN] AMINOISOXAZOLINE COMPOUNDS AS AGONISTS OF ALPHA7-NICOTINIC ACETYLCHOLINE RECEPTORS<br/>[FR] COMPOSÉS D'AMINOISOXAZOLINE EN TANT QUE RÉCEPTEURS NICOTINIQUES ALPHA7 DE L'ACÉTYLCHOLINE
  申请人：FORUM PHARMACEUTICALS INC

  公开号：WO2017069980A1

  公开（公告）日：2017-04-27

  The present invention relates to novel aminoisoxazoline compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of α7-nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.

  本发明涉及新型氨基异噁唑啉化合物及其药物组合物，适用作α7-nAChR的激动剂或部分激动剂，以及制备这些化合物和组合物的方法，以及在维持、治疗和/或改善认知功能的方法中使用这些化合物和组合物，特别是将该化合物或组合物用于需要的患者的给药方法，例如患有认知缺陷和/或希望增强认知功能的患者，可能从中获益。
• ZEMTSOVA, M. N.;TRAXTENBERG, P. L.;KALININA, M. N.;GOLOVANOVA, T. YU.;ZUD+, XIMIYA I TEXNOL. EHLEMENTOORGAN. POLUPRODUKTOV I POLIMEROV, VOLGOGRAD, 19+
  作者：ZEMTSOVA, M. N.、TRAXTENBERG, P. L.、KALININA, M. N.、GOLOVANOVA, T. YU.、ZUD+

  DOI：——

  日期：——
• AMINOISOXAZOLINE COMPOUNDS AS AGONISTS OF ALPHA7-NICOTINIC ACETYLCHOLINE RECEPTORS
  申请人：Axovant Sciences GmbH

  公开号：EP3365061A1

  公开（公告）日：2018-08-29
• Aminoisoxazoline Compounds as Agonists of Alpha7-Nicotinic Acetylcholine Receptors
  申请人：Forum Pharmaceuticals, Inc.

  公开号：US20170247393A1

  公开（公告）日：2017-08-31

  The present invention relates to novel aminoisoxazoline compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of α7-nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.
• METH-COHN O.; NARINE B., SYNTHESIS, 1980, NO 2, 133-135
  作者：METH-COHN O.、 NARINE B.

  DOI：——

  日期：——