1-Butan-2-yl-4-(3-methylphenyl)piperazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-Butan-2-yl-4-(3-methylphenyl)piperazine
• 英文别名: 1-butan-2-yl-4-(3-methylphenyl)piperazine
• 化学式: C₁₅H₂₄N₂
• 分子量: 232.36
• InChiKey: JBWXWWKCJQJGSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• TRIAZACYCLODODECANSULFONAMIDE ("TCD")-BASED PROTEIN SECRETION INHIBITORS
  申请人：KEZAR LIFE SCIENCES

  公开号：US20210078974A1

  公开（公告）日：2021-03-18

  Provided herein are triazacyclododecansulfonamide (“TCD”)-based protein secretion inhibitors, such as inhibitors of Sec61, methods for their preparation, related pharmaceutical compositions, and methods for using the same. For example, provided herein are compounds of Formula (I) and pharmaceutically acceptable salts and compositions including the same. The compounds disclosed herein may be used, for example, in the treatment of diseases including inflammation and/or cancer.