N-methyl-3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione | 52498-52-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-methyl-3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione
• 英文别名: 3-(4-amino-phenyl)-3-ethyl-1-methyl-piperidine-2,6-dione；3-(4-Aminophenyl)-3-ethyl-1-methylpiperidine-2,6-dione
• CAS: 52498-52-9
• 化学式: C₁₄H₁₈N₂O₂
• 分子量: 246.309
• InChiKey: DXAIZDIPLHVUSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  63.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  S-methyl benzenethiosulfonate 、 N-methyl-3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione 在 lithium diisopropyl amide 作用下， 生成 N-methyl-3-(4-aminophenyl)-3-ethyl-5-methylthiopiperidine-2,6-dione
  参考文献：
  名称：

  Seitz, David E.; Needham, Fang-Ling, Journal of Heterocyclic Chemistry, 1981, vol. 18, p. 687 - 689

  摘要：

  DOI：
• 作为产物：
  描述：

  氨鲁米特 生成 N-methyl-3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione
  参考文献：
  名称：

  SEAGO, ALISON;BAKER, MICHAEL H.;HOUGHTON, JOHN;JARMAN, MICHAEL;LEUNG, CHU+, BIOCHEM. PHARMACOL., 37,(1988) N 11, C. 2167-2172

  摘要：

  DOI：

文献信息

• SEITZ D. E.; NEEDHAM F.-L., J. HETEROCYCL. CHEM., 1981, 18, NO 4, 687-689
  作者：SEITZ D. E.、 NEEDHAM F.-L.

  DOI：——

  日期：——
• SEAGO, ALISON;BAKER, MICHAEL H.;HOUGHTON, JOHN;JARMAN, MICHAEL;LEUNG, CHU+, BIOCHEM. PHARMACOL., 37,(1988) N 11, C. 2167-2172
  作者：SEAGO, ALISON、BAKER, MICHAEL H.、HOUGHTON, JOHN、JARMAN, MICHAEL、LEUNG, CHU+

  DOI：——

  日期：——
• Multi-API Loading Prodrugs
  申请人：Alkermes Pharma Ireland Limited

  公开号：US20160024011A1

  公开（公告）日：2016-01-28

  The present invention accomplishes this by having multiple molecules of parent drugs attached to carrier moieties and by extending the period during which the parent drug is released and absorbed after administration to the patient and providing a longer duration of action per dose than the parent drug itself. Prodrug conjugates are suitable for sustained delivery of heteroaryl, lactam-amide-, imide-, sulfonamide-, carbamate-, urea-, benzamide-, acylaniline-, cyclic amide- and tertiary amine-containing parent drugs that are substituted at the amide nitrogen or oxygen atom with labile aldehyde-linked prodrug moieties. The carrier groups of the prodrugs can be hydrophobic to reduce the polarity and solubility of the parent drug under physiological conditions.
• MULTI-API LOADING PRODRUGS
  申请人：Alkermes Pharma Ireland Limited

  公开号：US20180194732A1

  公开（公告）日：2018-07-12

  The present invention accomplishes this by having multiple molecules of parent drugs attached to carrier moieties and by extending the period during which the parent drug is released and absorbed after administration to the patient and providing a longer duration of action per dose than the parent drug itself. Prodrug conjugates are suitable for sustained delivery of heteroaryl, lactam- amide-, imide-, sulfonamide-, carbamate-, urea-, benzamide-, acylaniline-, cyclic amide- and tertiary amine-containing parent drugs that are substituted at the amide nitrogen or oxygen atom with labile aldehyde-linked prodrug moieties. The carrier groups of the prodrugs can be hydrophobic to reduce the polarity and solubility of the parent drug under physiological conditions.
• Seitz, David E.; Needham, Fang-Ling, Journal of Heterocyclic Chemistry, 1981, vol. 18, p. 687 - 689
  作者：Seitz, David E.、Needham, Fang-Ling

  DOI：——

  日期：——