1-(4,4'-dimethoxytrityloxy)-4-(p-methoxybenzyloxy)-2-methylenebutane | 289486-03-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 1-(4,4'-dimethoxytrityloxy)-4-(p-methoxybenzyloxy)-2-methylenebutane
• 英文别名: 1-[3-[[Bis(4-methoxyphenyl)-phenylmethoxy]methyl]but-3-enoxymethyl]-4-methoxybenzene；1-[3-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]but-3-enoxymethyl]-4-methoxybenzene
• CAS: 289486-03-9
• 化学式: C₃₄H₃₆O₅
• 分子量: 524.657
• InChiKey: NPGYXQMGPHCYGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  39
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  46.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-(4,4'-dimethoxytrityloxy)-4-(p-methoxybenzyloxy)-2-methylenebutane 在 溶剂黄146 作用下， 以 水 为溶剂， 反应 0.5h， 以89%的产率得到4-[(4-methoxybenzyl)oxy]-2-methylenebutan-1-ol
  参考文献：
  名称：

  Synthesis of Unsaturated Carboacyclic Nucleoside Analogues via Mitsunobu Reactions

  摘要：

  2-Substituted allyl alcohols 9 and 14 were prepared starting from butane-1,2,4-triol and glycerol, respectively. Mitsunobu condensations of 9 and 14 with purine and pyrimidine bases, followed by deprotection, afforded a number of acyclonucleosides having 4-hydroxy-2-methylenebutyl or 3,3-bis(hydroxymethyl)-2-methylenepropyl chain.

  DOI：

  10.1080/15257770008033028
• 作为产物：
  描述：

  4-[2-(4-methoxy-benzyloxy)ethyl]-2,2-dimethyl-[1,3]dioxolane 在 吡啶 、 盐酸 、 sodium tert-pentoxide 、 N,N'-二环己基碳二亚胺 、 三氟乙酸 作用下， 以 甲醇 、 乙醚 、 二氯甲烷 、 水 、 二甲基亚砜 、 苯 为溶剂， 反应 162.5h， 生成 1-(4,4'-dimethoxytrityloxy)-4-(p-methoxybenzyloxy)-2-methylenebutane
  参考文献：
  名称：

  Synthesis of Unsaturated Carboacyclic Nucleoside Analogues via Mitsunobu Reactions

  摘要：

  2-Substituted allyl alcohols 9 and 14 were prepared starting from butane-1,2,4-triol and glycerol, respectively. Mitsunobu condensations of 9 and 14 with purine and pyrimidine bases, followed by deprotection, afforded a number of acyclonucleosides having 4-hydroxy-2-methylenebutyl or 3,3-bis(hydroxymethyl)-2-methylenepropyl chain.

  DOI：

  10.1080/15257770008033028

文献信息

• Synthesis of Unsaturated Carboacyclic Nucleoside Analogues via Mitsunobu Reactions
  作者：Jinfa Du、Guangyi Wang

  DOI：10.1080/15257770008033028

  日期：2000.5

  2-Substituted allyl alcohols 9 and 14 were prepared starting from butane-1,2,4-triol and glycerol, respectively. Mitsunobu condensations of 9 and 14 with purine and pyrimidine bases, followed by deprotection, afforded a number of acyclonucleosides having 4-hydroxy-2-methylenebutyl or 3,3-bis(hydroxymethyl)-2-methylenepropyl chain.