6-Chloro-3-[(Z)-(isonicotinoylhydrazono)(2,4,6-trioxohexahydro-5-pyrimidinyl)methyl]-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻二嗪
• 英文名称: 6-Chloro-3-[(Z)-(isonicotinoylhydrazono)(2,4,6-trioxohexahydro-5-pyrimidinyl)methyl]-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• 英文别名: N-[(Z)-[(6-chloro-1,1-dioxo-7-sulfamoyl-4H-1λ6,2,4-benzothiadiazin-3-yl)-(2,4,6-trioxo-1,3-diazinan-5-yl)methylidene]amino]pyridine-4-carboxamide
• 化学式: C₁₈H₁₃ClN₈O₈S₂
• 分子量: 568.9
• InChiKey: CGIFIFRHVCDHOB-MXAYSNPKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  37
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  265
• 氢给体数：
  5
• 氢受体数：
  12

文献信息

• ISONIAZID MEDIATED HEALING OF WOUNDS AND ULCERS
  申请人：Buxbom Finn

  公开号：US20100184811A1

  公开（公告）日：2010-07-22

  The invention relates to the use of a compound(s) selected from isoniazid and isoniazid analogs of formula Ia, wherein R is —C(O)NHNH 2 , —C(O)NHNHC 1-6 alkyl, —C(O)NHN═C 1-6 alkenyl, —C(O)NHNHC 2-6 alkenyl, —C(O)NHC 1-6 alkyl, —C(O)NHC 2-6 alkenyl, —C(O)NHNHC(O)C 1-6 alkyl, —NHC(O)C 1-6 alkyl, —NHC(O)C 1-6 alkenyl, —NHC(O)NH 2 , —NHC(O)NHC 1-6 alkyl, —NHC(O)NHC 2-6 alkenyl, or —COOH, and wherein formula (Ia) optionally is further substituted with one or more substituents; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the preparation of a pharmaceutical composition for treating a condition selected from the group consisting of cutaneous lesions, wounds, ulcers and infarcts in a tissue area with compromised vascularisation, in an animal, such as a human subject. The compound is preferably isoniazid, or pharmaceutical acceptable salts, solvates or prodrugs thereof, and the conditions to be treated is for example selected from the group consisting of pressure ulcers, diabetic ulcers, arterial ulcers and anastomotic ulcers. The invention furthermore relates to a method of treating a condition selected from wounds, ulcers or infarcts in a tissue area with compromised vascularisation in an animal, such as a human subject.