Arachidyl-N-sphingosin | 315710-08-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 鞘脂
• 英文名称: Arachidyl-N-sphingosin
• 英文别名: N-eicosanoyl-D-sphingosine；C20 Ceramide；N-[(E)-1,3-dihydroxyoctadec-4-en-2-yl]icosanamide
• CAS: 315710-08-8
• 化学式: C₃₈H₇₅NO₃
• 分子量: 594.018
• InChiKey: XWBWIAOWSABHFI-QOSDPKFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  15
• 重原子数：
  42
• 可旋转键数：
  34
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• POLYETHYLENE GLYCOL MODIFIED CERAMIDE LIPIDS AND LIPOSOME USES THEREOF
  申请人：THE UNIVERSITY OF BRITISH COLUMBIA

  公开号：EP0783297A1

  公开（公告）日：1997-07-16
• POLYETHYLENE GLYCOL MODIFIED CERAMIDE LIPIDS AND LIPOSOMES
  申请人：THE UNIVERSITY OF BRITISH COLUMBIA

  公开号：EP0783297B1

  公开（公告）日：1999-03-24
• METHODS FOR EARLY DETECTION OF HEART DISEASE
  申请人：Lpath, Inc.

  公开号：EP0988552B1

  公开（公告）日：2010-11-24
• COMPOSITIONS AND METHODS FOR PROMOTING HEALTHY NEURAL DEVELOPMENT IN AN UNBORN BABY
  申请人：The Regents of the University of California

  公开号：EP3965820A1

  公开（公告）日：2022-03-16
• Compositions and methods for the treatment and prevention of cancer, angiogenesis, and inflammation
  申请人：Sabbadini A. Roger

  公开号：US20070212348A1

  公开（公告）日：2007-09-13

  Methods and compositions are disclosed that are useful for the prevention and/or treatment of cancer, angiogenesis, and inflammation. The beneficial effects of the compositions and methods are achieved through the use of pharmaceutical compositions that include agents that bind sphingolipids or sphingolipid metabolites. In one embodiment the agent is an antibody or antibody derivative. In some embodiments, the agent is a receptor of a sphingolipid or a sphingolipid metabolite. Also disclosed are methods for identifying and isolating therapeutic agents.