Alentemol | 112891-97-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 非那烯类
• 英文名称: Alentemol
• 英文别名: 5-(dipropylamino)-5,6-dihydro-4H-phenalen-2-ol
• CAS: 112891-97-1
• 化学式: C₁₉H₂₅NO
• 分子量: 283.4
• InChiKey: TWUJBHBRYYTEDL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (5-Methoxy-2,3-dihydro-1H-phenalen-2-yl)-dipropyl-amine 、 氢溴酸 以63%的产率得到
  参考文献：
  名称：

  DARLINGTON, W. H.;SZMUSZKOVICZ, J., TETRAHEDRON LETT., 29,(1988) N 16, 1883-1886

  摘要：

  DOI：

文献信息

• 2,3-Dihydro-1H-phenalene-2-amino compounds as anti-psychotic drugs
  申请人：THE UPJOHN COMPANY

  公开号：EP0234113A1

  公开（公告）日：1987-09-02

  2-3-Dihydro-1H-phenalene-2-amino compounds of the formula some of which are new, e.g., 2-3-dihydro-2-(N,N-di-n-propylamino)-1H-phenalen-5-ol, and pharmaceutically acceptable salts of such compounds have been found to be useful anti-psychotic drug compounds.

  已发现 2-3-二氢-1H-苯丙烯-2-氨基化合物（其中一些是新式化合物，如 2-3-二氢-2-（N,N-二正丙基氨基）-1H-苯丙烯-5-醇）以及此类化合物的药学上可接受的盐类是有用的抗精神病药物化合物。
• [EN] 2,3-DIHYDRO-1H-PHENALENE-2-AMINO COMPOUNDS AS ANTI-PSYCHOTIC DRUGS
  申请人：THE UPJOHN COMPANY

  公开号：WO1987004153A1

  公开（公告）日：1987-07-16

  (EN) 2,3-Dihydro-1H-phenalene-2-amino compounds of formula (I), some of which are new, e.g., 2,3-dihydro-2-(N,N-di-n-propylamino)-1H-phenalen-5-ol, and pharmaceutically acceptable salts of such compounds have been found to be useful anti-psychotic drug compounds.(FR) On a découvert que des composés de 2,3-dihydro-1H-phénalène-2-amine ayant la formule (I), dont certains sont de nouveaux composés, tels que 2,3-dihydro-2-(N,N-di-n-propylamino)-1H-phénalène-5-ol, et leurs sels pharmaceutiquement acceptables, constituent des composés utiles pour des médicaments anti-psychotiques.

  具有化学式（I）的2,3-双氢-1H-苯并吡咯-2-氨化合物，其中有些是新型化合物，例如2,3-双氢-2-(N,N-二-n-丙基氨基)-1H-苯并吡咯-5-ol，以及这种化合物的药用上可接受的盐类被发现是有用的抗精神病药物。
• 2,3-DIHYDRO-1H-PHENALENE-2-AMINO COMPOUNDS AS ANTI-PSYCHOTIC DRUGS
  申请人：THE UPJOHN COMPANY

  公开号：EP0288477A1

  公开（公告）日：1988-11-02
• Combination of a dopamine D2-receptor agonist and tiotropium or a derivative therof for treating obstructive airways and other inflammatory diseases
  申请人：Yeadon Michael

  公开号：US20070117788A1

  公开（公告）日：2007-05-24

  The present invention relates to a combination of therapeutic agents useful in the treatment of obstructive airways and other inflammatory diseases comprising (I) a dopamine D2-receptor agonist that is therapeutically effective in the treatment of said diseases when administered by inhalation; together with (II) an anti-cholinergic agent consisting of a member selected from the group consisting of tiotropium and derivatives thereof that is therapeutically effective in the treatment of said diseases when administered by inhalation; as well as to a method of treating said obstructive airways and other inflammatory diseases comprising administering to said mammal by inhalation a therapeutically effective amount of said combination of therapeutic agents; and a pharmaceutical composition comprising a pharmaceutically acceptable carrier together with said combination of therapeutic agents; and a package containing a pharmaceutical composition for insertion into a device capable of simultaneous or sequential delivery of said pharmaceutical composition in the form of an aerosol or dry powder dispersion to said mammal, where said device is a metered dose inhaler or a dry powder inhaler. It is preferred that said dopamine D2-receptor agonist component be bromocriptine mesylate, naxagolide hydrochloride, cabergoline, pergolide mesylate, quinpirole hydrochloride, or ropinirole hydrochloride; and that said anti-cholinergic agent component be tiotropium bromide.
• [EN] ANTIPSYCHOTIC AMINO-POLYHYDRO-BENZ-(ISO)QUINOLINES AND INTERMEDIATES
  申请人：THE UPJOHN COMPANY

  公开号：WO1988004292A1

  公开（公告）日：1988-06-16

  (EN) Amino-polyhydro-benz-(iso)quinoline compounds of formula (I), wherein X, Y, Z, R1, R2, R3 are as defined in the specification, e.g., 3aS-trans-5-(N,N-di-n-propylamino)-3a,4,5,6-tetrahydro-1H-benzo de quinolin-2(3H)one, or pharmacologically acceptable salts thereof, are useful as antipsychotic drugs or as intermediates for making such compounds. Pharmaceutical compositions and methods of using these compounds are also provided. Processes for preparing the compounds are provided.(FR) Les composés d'amino-polyhydro-benzo-(iso)quinoléine de formule (I) dans laquelle X, Y, Z, R1, R2, R3 sont tels que definis dans la description, par exemple la (N,N-di-n-propylamino) 3a5-trans-5-tetrahydro-3a,4,5,6-benzo-1H-quinolein-2(3H)one, ou des sels pharmaceutiques de celle-ci, sont utiles à titre de médicaments antipsychotiques ou comme produits intermédiaires pour la fabrication de tels composés. Des compositions pharmaceutiques et des procédés d'utilisation de tels composés sont également prévus, ainsi que des procédés de préparation des composés.