hydron;1-(2-methylphenyl)piperazine;dichloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: hydron;1-(2-methylphenyl)piperazine;dichloride
• 化学式: C11H18Cl2N2
• mdl: MFCD00039030
• 分子量: 249.18
• InChiKey: NCENNBIPRYOJSP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.06
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  15.3
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-chloro-2,6-bis-(2-hydroxy-ethylamino)-pyrimidine-5-carbonitrile 、 hydron;1-(2-methylphenyl)piperazine;dichloride 、 N,N-二异丙基乙胺 以 1,4-二氧六环 为溶剂， 以to yield 2,4-bis-(2-hydroxy-ethylamino)-6-(4-o-tolyl-piperazin-1-yl)-pyrimidine-5-carbonitrile as an amorphous, light brown solid的产率得到2,4-bis-(2-hydroxy-ethylamino)-6-(4-o-tolyl-piperazin-1-yl)-pyrimidine-5-carbonitrile
  参考文献：
  名称：

  Pyrimidine, pyrazine and triazane derivatives

  摘要：

  本发明是一种嘧啶、三嗪或吡嗪衍生物，其化学式为或其药学上可接受的盐，其中R1、R2、R3、R4、X、Y和Z如规范中所定义。本发明是一种含有化合物1的有效量的药物组合物，以及其制备和通过给予化合物1的治疗、控制或预防急性和/或慢性神经疾病的方法。

  公开号：

  US06673795B2

文献信息

• Arylpiperazine Derivatives and their Use as Selective Dopamine D3 Receptor Ligands
  申请人：Capet Marc

  公开号：US20080214542A1

  公开（公告）日：2008-09-04

  The invention concerns compounds of general formula (I), a method for preparing same, as well as their use as therapeutic agent.

  这项发明涉及一般式（I）的化合物，以及制备这些化合物的方法，以及它们作为治疗剂的用途。
• Compounds II
  申请人：Boyd Joseph W.

  公开号：US20090281087A1

  公开（公告）日：2009-11-12

  The present application relates to new compounds of formula (I), to pharmaceutical compositions comprising the compounds, to processes for their preparation, and to the use of the compounds as leptin receptor modulator mimetics in the preparation of medicaments against conditions associated with weight gain, type 2 diabetes and dyslipidemias.

  本申请涉及式(I)的新化合物，包含该化合物的药物组合物，它们的制备过程，以及将这些化合物用作瘦素受体调节剂拟态物，用于制备治疗与体重增加、2型糖尿病和高脂血症相关的药物。
• Pyrimidine, pyrazine and triazine derivatives
  申请人：——

  公开号：US20030060466A1

  公开（公告）日：2003-03-27

  The present invention is a pyrimidine, triazine or pyrazine derivative of the formula 1 or a pharmaceutically acceptable salt thereof wherein R 1 , R 2 , R 3 , R 4 , X, Y and Z are as defined in the specification. The invention is a pharmaceutical composition containing an effective amount of the compound of formula 1, its preparation and to a method of treatment, control or prevention of acute and/or chronic neurological disorders by administering a therapeutically effective amount of a compound of formula 1.

  本发明是一种嘧啶、三嗪或吡嗪衍生物的化学式1或其药用盐，其中R1、R2、R3、R4、X、Y和Z如规范中定义。该发明是一种含有化学式1化合物的有效量的药物组合物，以及其制备方法和通过给予化学式1化合物的治疗有效量来治疗、控制或预防急性和/或慢性神经系统疾病的方法。
• [EN] NOVEL BENZODIOXOLES<br/>[FR] NOUVEAUX BENZODIOXOLES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2004013120A1

  公开（公告）日：2004-02-12

  The present invention relates to compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases, which are associated with the modulation of CB1 receptors.

  本发明涉及具有式（I）的化合物，其中R1、R2、R3、R4、R5、R6、R7和X如描述和权利要求中所定义，并且其药学上可接受的盐。这些化合物可用于治疗和/或预防与CB1受体调节相关的疾病。
• [EN] N-PHENYL-(PIPERAZINYL OR HOMOPIPERAZINYL)-BENZENESULFONAMIDE OR BENZENESULFONYL-PHENYL-(PIPERAZINE OR HOMOPIPERAZINE) COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE SEROTONIN 5-HT6 RECEPTOR<br/>[FR] COMPOSÉS N-PHÉNYL-(PIPÉRAZINYL OU HOMOPIPÉRAZINYL)- BENZÈNESULFONAMIDE OU BENZÈNESULFONYL-PHÉNYL-(PIPÉRAZINE OU HOMOPIPÉRAZINE) ADAPTÉS AU TRAITEMENT DE TROUBLES RÉPONDANT À LA MODULATION DU RÉCEPTEUR 5-HT6 DE LA SÉROTONINE
  申请人：ABBOTT GMBH & CO KG

  公开号：WO2010125134A1

  公开（公告）日：2010-11-04

  The present invention relates to N-phenyl-(piperazinyl or homopiperazinyl)- benzenesulfonamide or benzenesulfonyl-phenyl-(piperazine or homopiperazine) compounds,pharmaceutical compositions containing them, and their use in therapy. The compounds possess valuable therapeutic properties and are particularly suitable for treating diseases that respond to modulation of the serotonin 5-HT6 receptor. wherein X is a bond or a group N-R4; R1 is hydrogen or methyl; R2 is hydrogen or methyl; R3 is hydrogen, C1-C3 alkyl, fluorine, C1-C2 alkoxy or fluorinated C1-C2 alkoxy; R4 is hydrogen, C1-C4 alkyl, C3-C4 cycloalkyl, or C3-C4 cycloalkyl-CH2-; R5 is hydrogen, fluorine, chlorine, C1-C2 alkyl, fluorinated C1-C2 alkyl, C1-C2 alkoxy or fluorinated C1-C2 alkoxy; R6 is hydrogen, fluorine or chlorine; and n is 1 or 2.

  本发明涉及N-苯基-(哌嗪基或同源哌嗪基)-苯磺酰胺或苯磺酰基-苯基-(哌嗪或同源哌嗪)化合物，含有它们的药物组合物，以及它们在治疗中的应用。这些化合物具有有价值的治疗特性，特别适用于治疗对5-羟色胺5-HT6受体调节有响应的疾病。其中X是键或基团N-R4；R1是氢或甲基；R2是氢或甲基；R3是氢，C1-C3烷基，氟，C1-C2烷氧基或氟代C1-C2烷氧基；R4是氢，C1-C4烷基，C3-C4环烷基，或C3-C4环烷基-CH2-；R5是氢，氟，氯，C1-C2烷基，氟代C1-C2烷基，C1-C2烷氧基或氟代C1-C2烷氧基；R6是氢，氟或氯；n为1或2。