9-hydroxynorpseudopelletierine | 19918-88-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 9-hydroxynorpseudopelletierine
• 英文别名: 9-hydroxy-9-aza-bicyclo[3.3.1]nonan-3-one；9-Hydroxy-9-azabicyclo[3.3.1]nonan-3-one
• CAS: 19918-88-8
• 化学式: C₈H₁₃NO₂
• 分子量: 155.197
• InChiKey: KCMINNPTGLFCCL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-((35-azido-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontyl)oxy)isoindoline-1,3-dione 、 9-hydroxynorpseudopelletierine 在 肼 、 溶剂黄146 作用下， 以 乙醇 、 水 、 甲醇 为溶剂， 反应 26.0h， 以28%的产率得到N²-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzoyl)-N5-((1-(35-((((1R,5S,Z)-9-hydroxy-9-azabicyclo[3.3.1]nonan-3-ylidene)amino)oxy)-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontyl)-1H-1,2,3-triazol-4-yl)methyl)-Lglutamine
  参考文献：
  名称：

  Synthesis of Tryptophan–Folate Conjugates

  摘要：

  描述了一种合成叶酸-肽/蛋白共轭物靶向色氨酸残基的温和协议。这种合成协议有利于将对化学敏感的叶酸均匀连接到生物分子上，具有潜在的在癌症治疗和诊断中的应用。

  DOI：

  10.1055/s-0039-1691735

文献信息

• COMPOUND HAVING AFFINITY SUBSTANCE TO SOLUBLE PROTEIN, CLEAVABLE PORTION AND REACTIVE GROUP, OR SALT THEREOF
  申请人：Ajinomoto Co., Inc.

  公开号：US20200190165A1

  公开（公告）日：2020-06-18

  The present invention provides a technique enabling modification of a soluble protein and in particular regioselective modification of a soluble protein. More specifically, the present invention provides a compound having an affinity substance to a soluble protein, a cleavable portion, and a reactive group represented by the following Formula (I): A-L-B-R  (I) wherein A is an affinity substance to a soluble protein; L is a cleavable linker which is a divalent group comprising a cleavable portion; B is (a) a divalent group comprising a bioorthogonal functional group or (b) a divalent group comprising no bioorthogonal functional group; and R is a reactive group to the soluble protein; or a salt thereof.
• COMPOSITION FOR HOLOGRAPHIC RECORDING MEDIUM, AND HOLOGRAPHIC RECORDING MEDIUM
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：US20210116805A1

  公开（公告）日：2021-04-22

  A holographic recording medium composition comprising component (e): a compound having an isocyanate group or an isocyanate-reactive functional group and further having a nitroxyl radical group, wherein component (e) contains component (e-1) below: component (e-1): a compound having a heterobicyclic ring structure or a heterotricyclic ring structure, the heterobicyclic ring structure or the heterotricyclic ring structure being obtained by replacing a carbon atom in a bicyclic ring structure or a tricyclic ring structure by the nitroxyl radical group.
• COMPOUND HAVING AFFINITY SUBSTANCE TO ANTIBODY, CLEAVABLE PORTION, AND REACTIVE GROUP, OR SALT THEREOF
  申请人：Ajinomoto Co., Inc.

  公开号：US20210300972A1

  公开（公告）日：2021-09-30

  Compounds having an affinity substance to an antibody, a cleavable portion, and a reactive group, or a salt thereof, are represented by the following Formula (I): A-L-B—R  (I) wherein A is an affinity substance to an antibody, L is a cleavable linker that is a divalent group comprising a cleavable portion, B is (a) a divalent group comprising a bioorthogonal functional group or (b) a divalent group comprising no bioorthogonal functional group, and R is a reactive group to the antibody, wherein the affinity substance to an antibody is a polypeptide comprising a glutamine residue (Q) at an N-terminal.
• Synthesis of Tryptophan–Folate Conjugates
  作者：Kounosuke Oisaki、Motomu Kanai、Katsuya Maruyama、Katarzyna Joanna Malawska、Natsuki Konoue

  DOI：10.1055/s-0039-1691735

  日期：2020.5

  A mild protocol for the synthesis of folate–peptide/protein conjugates targeting tryptophan residues is described. This synthetic protocol is advantageous for homogeneous conjugation of chemically sensitive folates to biomolecules, with potential applications in cancer therapy and diagnostics.

  描述了一种合成叶酸-肽/蛋白共轭物靶向色氨酸残基的温和协议。这种合成协议有利于将对化学敏感的叶酸均匀连接到生物分子上，具有潜在的在癌症治疗和诊断中的应用。