4-<4-Methoxy-phenyl>-1-<3,4-dimethoxy-phenethyl>-piperazin | 1052-26-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-<4-Methoxy-phenyl>-1-<3,4-dimethoxy-phenethyl>-piperazin
• 英文别名: 1-(3,4-dimethoxy-phenethyl)-4-(4-methoxy-phenyl)-piperazine；Piperazine, 1-(3,4-dimethoxyphenethyl)-4-(p-methoxyphenyl)-；1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(4-methoxyphenyl)piperazine
• CAS: 1052-26-2
• 化学式: C₂₁H₂₈N₂O₃
• 分子量: 356.465
• InChiKey: XILTUGULAKXPOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  34.2
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues
  申请人：Hutchison Alan

  公开号：US20050182068A1

  公开（公告）日：2005-08-18

  Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).

  提供了黑色素浓集激素受体配体（尤其是1-苄基-4-芳基哌嗪，1-苄基-4-芳基哌啶和相关化合物），能够调节MCH受体活性。这样的配体可用于调节体内或体外MCH结合到MCH受体，并且在人类、家养伴侣动物和家畜动物的多种代谢、进食和性疾病治疗中特别有用。提供了用于治疗此类疾病的制药组合物和方法，以及用于检测MCH受体的配体的方法（例如受体定位研究）。
• MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED 1-BENZYL-4-ARYL PIPERAZINE ANALOGUES
  申请人：NEUROGEN CORPORATION

  公开号：EP1389189A2

  公开（公告）日：2004-02-18
• COMBINATION THERAPY FOR WEIGHT MANAGEMENT
  申请人：NEUROGEN CORPORATION

  公开号：EP1729762A2

  公开（公告）日：2006-12-13
• EP1729762A4
  申请人：——

  公开号：EP1729762A4

  公开（公告）日：2007-12-19
• [EN] MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED 1-BENZYL-4-ARYL PIPERAZINE ANALOGUES<br/>[FR] LIGANDS RECEPTEURS DE L'HORMONE DE CONCENTRATION DE LA MELANINE: ANALOGUES DE 1-BENZYL-4-ARYL PIPERAZINE SUBSTITUEE
  申请人：NEUROGEN CORP

  公开号：WO2002094799A2

  公开（公告）日：2002-11-28

  Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptir activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).