2-[2-(4-(2-methoxyphenyl)-l-piperazinyl)ethyl]amino-5-acetyl-4,6-dimethylpyrimidine | 108381-26-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-[2-(4-(2-methoxyphenyl)-l-piperazinyl)ethyl]amino-5-acetyl-4,6-dimethylpyrimidine
• 英文别名: 1-(2-((2-(4-(2-Methoxyphenyl)-1-piperazinyl)ethyl)amino)-4,6-dimethyl-5-pyrimidinyl)ethanone；1-[2-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethylamino]-4,6-dimethylpyrimidin-5-yl]ethanone
• CAS: 108381-26-6
• 化学式: C₂₁H₂₉N₅O₂
• 分子量: 383.494
• InChiKey: SASFUNXGPNBZOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  70.6
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• SUSTAINED-RELEASE PREPARATION CONTAINING 5-ACETYL-4,6-DIMETHYL-2- 2- 4-(2-METHOXYPHENYL)PIPERAZINYL]ETHYLAMINO]PYRIMIDINE TRIHYDROCHLORIDE AS ACTIVE INGREDIENT
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1334723A1

  公开（公告）日：2003-08-13

  A sustained-release formulation of 5-acetyl-4,6-dimethyl-2-[2-[4-(2-methoxyphenyl)piperazinyl]ethylamino]pyrimidine trihydrochloride coated with a release-controlling film comprising a water-insoluble polymer film having no hydrophilic group. The formulation of the present invention has such a release pattern that the drug release lasts for 20 hours or more, so that can be appropriately administered for treatment. Furthermore, the formulation itself is so stable that its release pattern does not change with pH and the formulation does not suffer from deterioration, coloration and the like with the lapse of time.

  一种 5-乙酰基-4,6-二甲基-2-[2-[4-(2-甲氧基苯基)哌嗪基]乙基氨基]三盐酸嘧啶的缓释制剂，该制剂涂有一层释放控制膜，该膜由不含亲水基团的水不溶性聚合物膜组成。本发明的制剂具有这样一种释放模式，即药物释放可持续 20 小时或更长时间，因此可以适当地用于治疗。此外，本发明制剂本身非常稳定，其释放模式不会随酸碱度的变化而改变，也不会随着时间的推移而变质、变色等。
• EP1334723A4
  申请人：——

  公开号：EP1334723A4

  公开（公告）日：2005-08-31
• JPH0390027A
  申请人：——

  公开号：JPH0390027A

  公开（公告）日：1991-04-16
• US5075308A
  申请人：——

  公开号：US5075308A

  公开（公告）日：1991-12-24
• [EN] SUSTAINED-RELEASE PREPARATION CONTAINING 5-ACETYL-4,6-DIMETHYL-2-[2-[4-(2-METHOXYPHENYL)PIPERAZINYL]ETHYLAMINO]PYRIMIDINE TRIHYDROCHLORIDE AS ACTIVE INGREDIENT<br/>[FR] PREPARATION A LIBERATION PROLONGEE CONTENANT COMME PRINCIPE ACTIF DU TRIHYDROCHLORURE DE 5-ACETYL-4,6-DIMETHYL-2-(2-(4-(2-METHOXYPHENYL)PIPERAZINYL)ETHYLAMINO)PYRIMIDINE
  申请人：ONO PHARMACEUTICAL CO

  公开号：WO2002034268A1

  公开（公告）日：2002-05-02

  A sustained-release preparation of 5-acetyl-4,6-dimethyl-2-[2-[4-(2-methoxyphenyl)piperazinyl]ethylamino]pyrimidine trihydrochloride having a release-control coating film comprising a water-insoluble polymer having no hydrophilic groups. The preparation has such a release pattern that drug release lasts over 20 hours or more. It can be adequately administered for therapy. The preparation itself is so stable that its release pattern does not change with pH and the preparation does not suffer deterioration, coloration, etc. with time.