Hydrochlorothiazide hydrochloride | 42461-28-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻二嗪
• 英文名称: Hydrochlorothiazide hydrochloride
• 英文别名: 6-chloro-1,1-dioxo-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide;hydrochloride
• CAS: 42461-28-9
• 化学式: C7H9Cl2N3O4S2
• 分子量: 334.2
• InChiKey: HNLAFWZKHCUIMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.07
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  135
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• 2-Phenyl-3-azoylbenzothiophenes for treating menstrual symptoms
  申请人：ELI LILLY AND COMPANY

  公开号：EP0659421A1

  公开（公告）日：1995-06-28

  The present invention provides a method of alleviating one or more menstrual symptoms in a woman comprising administering to said woman in need of treatment an effective amount of a compound having the formula    wherein R¹ and R³ are independently hydrogen, -CH₃, -CO-(C₁-C₆ alkyl), or -CO-Ar in which Ar is optionally substituted phenyl; and    R² is selected from the group consisting of pyrrolidino, hexamethyleneimino and piperidino; or a pharmaceutically acceptable salt or solvate thereof. The present invention also provides the aforementioned method and further comprises administering to said woman an effective amount of at least one pharmaceutical agent selected from the group consisting of an analgesic, a diuretic, and an antihistamine, and compositions therefore.

  本发明提供了一种减轻妇女一种或多种月经症状的方法，包括向需要治疗的妇女施用有效量的式如下的化合物 其中 R¹ 和 R³ 独立地为氢、-CH₃、-CO-(C₁-C₆ 烷基)或-CO-Ar，其中 Ar 为任选取代的苯基；以及 R² 选自吡咯烷、六亚甲基亚氨基和哌啶组成的组；或其药学上可接受的盐或溶液。 本发明还提供了上述方法，并进一步包括向所述妇女施用有效量的至少一种选自镇痛剂、利尿剂和抗组胺剂组成的组的药剂及其组合物。
• Growth-promoting and immunizing subcutaneous implant
  申请人：Shuler O. Richard

  公开号：US20060252049A1

  公开（公告）日：2006-11-09

  The present invention relates generally to an implant for use in animals. More particularly, the present invention relates to an implant including a pharmaceutical agent and a biological agent for use in animals to promote growth, regulate metabolism and prevent illness or disease. A method for promoting growth and immunity in animal using an implant including a pharmaceutical agent and a biological agent. The implant is preferably administered to an animal subcutaneously.

  本发明一般涉及一种用于动物的植入物。更具体地说，本发明涉及一种植入物，包括一种药剂和一种生物制剂，用于动物促进生长、调节新陈代谢和预防疾病。一种使用包括药剂和生物制剂的植入物促进动物生长和免疫的方法。植入物最好皮下注射给动物。
• 2-Phenyl-3-aroylbenzothiophenes for treating menstrual symptoms
  申请人：ELI LILLY AND COMPANY

  公开号：EP0659421B1

  公开（公告）日：2003-03-12
• US5037823A
  申请人：——

  公开号：US5037823A

  公开（公告）日：1991-08-06
• US5155105A
  申请人：——

  公开号：US5155105A

  公开（公告）日：1992-10-13