6-chloro-1,1-dioxo-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide;3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide;hydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻二嗪
• 英文名称: 6-chloro-1,1-dioxo-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide;3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide;hydrochloride
• 化学式: C13H17Cl3N10O5S2
• 分子量: 563.8
• InChiKey: QRDAGKVHMGNVHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.22
• 重原子数：
  33
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  294
• 氢给体数：
  8
• 氢受体数：
  12

文献信息

• Methods of treating a subject for a condition
  申请人：PALO ALTO INVESTORS

  公开号：US10086071B2

  公开（公告）日：2018-10-02

  Methods are provided for treating a subject for at least one condition that includes inflammation, a blood clotting condition and autonomic nervous system dysfunction such as adrenergia, e.g., simultaneously. Also provided are kits for use in practicing the subject methods.

  提供了治疗受试者至少一种病症的方法，这些病症包括炎症、凝血病症和自律神经系统功能障碍，如肾上腺机能亢进症，例如，同时治疗。还提供了用于实施上述方法的试剂盒。
• Treatment of conditions through pharmacological modulation of the autonomic nervous system
  申请人：Palo Alto Investors

  公开号：US10702533B2

  公开（公告）日：2020-07-07

  Methods are provided for treating a subject for a condition caused by an abnormality in the subject's autonomic nervous system. In accordance with the subject methods, at least a portion of a subject's autonomic nervous system is pharmacologically modulated with at least one beta-blocker in a manner that is effective to treat the subject for the condition. The subject methods find use in the treatment of a variety of different conditions, where such conditions include various disease conditions. Also provided are systems and kits for use in practicing the subject methods.

  本研究提供了治疗受试者自律神经系统异常引起的疾病的方法。根据这些方法，用至少一种β-受体阻滞剂对受试者自律神经系统的至少一部分进行药理学调节，这种调节方式可有效治疗受试者的病症。这些方法可用于治疗各种不同的病症，这些病症包括各种疾病。此外，还提供了用于实施上述方法的系统和试剂盒。
• Methods and compositions for treating a renal disease condition in a subject
  申请人：Yun Anthony Joonkyoo

  公开号：US10716749B2

  公开（公告）日：2020-07-21

  Methods for treating a renal associated disease condition in a subject are provided. The subject methods are characterized by modulating at least one portion of the subject's autonomic nervous system in a manner effective to treat a renal condition in the subject. Specifically, the methods may include modulating, e.g., increasing, a parasympathetic/sympathetic activity ratio in the subject. Also provided are compositions, kits and systems for practicing the subject methods.

  本文提供了治疗受试者肾脏相关疾病的方法。这些方法的特点是以有效治疗受试者肾脏疾病的方式调节受试者自律神经系统的至少一个部分。具体来说，这些方法可包括调节，例如增加受试者的副交感神经/交感神经活动比率。此外，还提供了用于实施上述方法的组合物、试剂盒和系统。
• Treatment of conditions through modulation of the autonomic nervous system
  申请人：Yun Anthony Joonkyoo

  公开号：US10946197B2

  公开（公告）日：2021-03-16

  Methods are provided for treating a subject for a condition by modulating at least a portion of the subject's autonomic nervous system. In accordance with certain embodiments of the subject methods, at least a portion of a subject's autonomic nervous system is electrically or pharmacologically modulated in a manner that is effective to treat the subject for the condition. The subject methods find use in the treatment of a variety of different conditions, where such conditions include various disease conditions. Also provided are systems and kits for use in practicing the subject methods.

  本文提供了通过调节受试者至少一部分自律神经系统来治疗受试者病情的方法。根据主体方法的某些实施例，主体自律神经系统的至少一部分以有效治疗主体病症的方式进行电学或药理学调节。这些方法可用于治疗各种不同的病症，这些病症包括各种疾病。此外，还提供了用于实施上述方法的系统和试剂盒。
• Treatment of conditions through modulation of the autonomic nervous system during at least one predetermined menstrual cycle phase
  申请人：Yun Joonkyoo Anthony

  公开号：US20050256028A1

  公开（公告）日：2005-11-17

  Methods are provided for treating a subject for a condition. In accordance with the subject methods, at least a portion of a subject's autonomic nervous system is modulated during at least one predetermined phase of the subject's menstrual cycle to alter the parasympathetic activity/sympathetic activity ratio in a manner that is effective to treat the subject for the condition. The subject methods find use in the treatment of a variety of different conditions, including various disease conditions, that increase in severity and/or occurrence during one or more phases of the menstrual cycle. Also provided are systems and kits for use in practicing the subject methods.