1H-[1]benzofuro[3,2-c]pyrazole | 39514-51-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 1H-[1]benzofuro[3,2-c]pyrazole
• CAS: 39514-51-7
• 化学式: C₉H₆N₂O
• mdl: MFCD18807968
• 分子量: 158.16
• InChiKey: VMLKMYJTGAISQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  41.8
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Pyrazoles for the treatment of obesity and other CNS disorders
  申请人：Bennani L. Youssef

  公开号：US20070197526A1

  公开（公告）日：2007-08-23

  This invention relates to compounds having pharmacological activity, to compositions containing these compounds, and to a method of treatment employing the compounds and compositions. More particularly, this invention concerns certain pyrazole derivatives, their salts and solvates. These compounds have H 3 histamine receptor binding activity. This invention also relates to pharmaceutical compositions containing these compounds and to a method of treating disorders in which histamine H 3 receptor modulation is beneficial.

  这项发明涉及具有药理活性的化合物，含有这些化合物的组合物，以及使用这些化合物和组合物的治疗方法。更具体地，这项发明涉及某些吡唑类衍生物，它们的盐和溶剂化合物。这些化合物具有H3组胺受体结合活性。这项发明还涉及含有这些化合物的药物组合物，以及一种治疗组织中组胺H3受体调节有益的疾病的方法。
• PYRAZOLES FOR THE TREATMENT OF OBESITY AND OTHER CNS DISORDERS
  申请人：Bennani Youssef L.

  公开号：US20110112088A1

  公开（公告）日：2011-05-12

  This invention relates to compounds of the formula: to compositions containing these compounds, and to methods of treatment employing the compounds and compositions.

  本发明涉及以下公式的化合物：含有这些化合物的组合物以及使用这些化合物和组合物的治疗方法。
• Pyrazole derivatives as anti-inflammatory/analgesic agents
  申请人：——

  公开号：US20020115856A1

  公开（公告）日：2002-08-22

  The present invention relates to compounds of the formula 1 wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , n, p, W, X, Y and Z are defined as in the specification, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the invention are useful in the treatment or alleviation of inflammation and other inflammation associated disorders, such as arthritis, colon cancer, and Alzheimer's disease in mammals, preferably humans, dogs, cats, horses and livestock.

  本发明涉及式1的化合物，其中R1、R2、R3、R4、R5、R6、R7、R8、R9、R10、n、p、W、X、Y和Z定义如说明书所述，以及含有它们的制药组合物和它们的药用。本发明的化合物在哺乳动物中，特别是人类、狗、猫、马和家畜中，用于治疗或缓解炎症和其他炎症相关疾病，如关节炎、结肠癌和阿尔茨海默病等。
• Monomer for use in preparation of a polymer to be used in optical devices
  申请人：——

  公开号：US20040115473A1

  公开（公告）日：2004-06-17

  A monomer having general Formula (I) which may be substituted or unsubstituted: where E and E are the same or different and are reactive groups capable of undergoing chain extension; X is O, S, NR 5 , R 5 C—CR 6 or R 5 ═CR 6 ; Y is O, S, NR 7 , R 7 C—CR 8 or R 7 C═CR 8 ; R 5 , R 6 R 7 and R 8 are the same or different and each is independently H or a substituent group; and each Ar is the same or different and is independently a substituted or unsubstituted aryl or heteroaryl group. 1

  具有通式(I)的单体，可被取代或未被取代： 其中 E 和 E 是相同或不同的，并且是可进行链延伸的活性基团； X 是 O、S、NR 5 , R 5 C-CR 6 或 R 5 ═CR 6 Y 是 O、S、NR 7 , R 7 C-CR 8 或 R 7 C═CR 8 ; R 5 , R 6 R 7 和 R 8 相同或不同，且各自独立地为 H 或取代基；以及每个 Ar 相同或不同，且各自独立地为取代或未取代的芳基或杂芳基。 1
• MONOMER FOR USE IN PREPARATION OF A POLYMER TO BE USED IN OPTICAL DEVICES
  申请人：Cambridge Display Technology Limited

  公开号：EP1366046A1

  公开（公告）日：2003-12-03