N,N,4-Trimethylpiperazin-1-amine | 52722-82-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N,N,4-Trimethylpiperazin-1-amine
• CAS: 52722-82-4
• 化学式: C₇H₁₇N₃
• 分子量: 143.23
• InChiKey: DRKVIJXWFGFHDK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] NON-ATP/CATALYTIC SITE p38 MITOGEN ACTIVATED PROTEIN KINASE INHIBITORS<br/>[FR] INHIBITEURS DE PROTÉINE KINASE ACTIVÉS PAR LE MITOGÈNE P38 DE SITE NON ATP/CATALYTIQUE
  申请人：UNIV MARYLAND

  公开号：WO2020118194A1

  公开（公告）日：2020-06-11

  Compounds that inhibit p38α MAPK protein, and methods of using the same, are provided for treating or preventing diseases such as cancer or inflammatory diseases.

  提供了抑制p38α MAPK蛋白的化合物，以及使用这些化合物治疗或预防癌症或炎症性疾病的方法。
• SILANE MODIFIED FORMAMIDES
  申请人：COVESTRO DEUTSCHLAND AG

  公开号：US20160340371A1

  公开（公告）日：2016-11-24

  The invention relates to novel silane-modified formamides and/or pre-polymers for bonding and/or sealing diverse substrate materials, such as, for example metal, wood, glass and/or plastic, The invention also relates to a reactive single-component adhesive system comprising the claimed silane-modified formamide and/or pre-polymers.

  该发明涉及用于粘接和/或密封不同基材的新型硅烷改性甲酰胺和/或预聚合物，例如金属、木材、玻璃和/或塑料。该发明还涉及一种包括所述硅烷改性甲酰胺和/或预聚合物的反应性单组分胶粘系统。
• [EN] OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF<br/>[FR] COMPOSITIONS D'OLIGONUCLÉOTIDES ET PROCÉDÉS ASSOCIÉS
  申请人：WAVE LIFE SCIENCES LTD

  公开号：WO2021237223A1

  公开（公告）日：2021-11-25

  The present disclosure provides modified oligonucleotides and compositions and methods thereof. In some embodiments, provided technologies comprise modified sugars and/or modified internucleotidic linkages. In some embodiments, the present disclosure provides technologies for preparing modified oligonucleotides. In some embodiments, the present disclosure provides chirally controlled oligonucleotide compositions and methods for their preparation and uses.

  本公开提供了经修改的寡核苷酸及其组合物和方法。在某些实施方式中，提供的技术包括修改的糖或修改的核苷酸间连接。在某些实施方式中，本公开提供了用于制备修改的寡核苷酸的技术。在某些实施方式中，本公开提供了对手性控制的寡核苷酸组合物及其制备和用途的方法。
• SILANE-MODIFIED FORMAMIDES
  申请人：Covestro Deutschland AG

  公开号：US20160340372A1

  公开（公告）日：2016-11-24

  The invention relates to novel silane-modified formamide-polymers and/or pre-polymers for bonding and/or sealing diverse substrate materials, such as, for example metal, wood, glass and/or plastic. The invention also relates to a reactive single-component adhesive system comprising the claimed silane-modified formamide polymers.

  该发明涉及用于粘接和/或密封不同基材的新型硅烷改性甲酰胺聚合物和/或前聚物，例如金属、木材、玻璃和/或塑料。该发明还涉及一种包括所述硅烷改性甲酰胺聚合物的反应性单组分粘合系统。
• ISOCYANATOSILANES WITH THIOURETHANE STRUCTURE
  申请人：Bayer MaterialScience AG

  公开号：US20150246936A1

  公开（公告）日：2015-09-03

  The invention relates to a method for producing compounds containing isocyanate and silane groups by reacting at least A) one monomeric diisocyanate containing aliphatically, cycloaliphatically, araliphatically and/or aromatically bonded isocyanate groups with B) a mercaptosilane, characterised in that component A) is reacted with component B) in an equivalent ratio of isocyanate groups to mercapto groups of at least 06:01 to at most 40:1. Furthermore, the invention relates to the products which can be obtained using the method according to the invention, and to a composition containing compounds that contain isocyanate and silane groups. Moreover, the invention relates to the use of the products which can be obtained using the method according to the invention and the composition according to the invention as starting components in the production of silane group-containing polyurethanes, cross-linkable binders, varnish, and raw materials for sealants or adhesives.

  本发明涉及一种通过将至少A）一种含有脂肪族、环脂族、芳基脂肪族和/或芳香基结合的异氰酸酯基团的单体二异氰酸酯与B）巯基硅烷反应来生产含有异氰酸酯和硅烷基团的化合物的方法，其特征在于A）组分与B）组分以等当比例的异氰酸酯基团与巯基团反应，比例范围为至少06:01到最多40:1。此外，本发明涉及使用本发明方法可获得的产品，以及含有含有异氰酸酯和硅烷基团的化合物的组合物。此外，本发明还涉及使用本发明方法和组合物所得产品作为含硅烷基的聚氨酯、可交联粘合剂、清漆和密封剂或粘合剂的原材料的用途。