2-Methylpropyl 4-methylpiperazine-1-carboxylate | 94588-21-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-Methylpropyl 4-methylpiperazine-1-carboxylate
• CAS: 94588-21-3
• 化学式: C₁₀H₂₀N₂O₂
• mdl: MFCD26794228
• 分子量: 200.28
• InChiKey: DDDSFDHCNGGOHN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  32.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• (2E,4E)-5-PHENYL-PENTA-2,4-DIEN-1-ONE DERIVATIVE
  申请人：BIOWAY., INC

  公开号：US20200157048A1

  公开（公告）日：2020-05-21

  The present application relates to a novel pentadienoyl compound and a pharmaceutical composition including the same. The pentadienoyl compound of the present application may be used to prevent or treat fatty liver and fatty liver-related disease by inhibiting lipogenesis and lipid accumulation in cells and activating lipid metabolism. In addition, the pentadienoyl compound of the present application may increase a SIRT1 expression level in cells or SIRT1 activity, and thus may be used to prevent or treat a SIRT1-mediated disease. In addition, the pentadienoyl compound of the present application may reduce a CK2 expression level in cells or CK2 activity, and thus may be used to prevent or treat a CK2-mediated disease.

  本申请涉及一种新型的戊二烯酰化合物和包括该化合物的药物组合物。本申请的戊二烯酰化合物可用于通过抑制细胞内脂肪生成和脂质积累，激活脂质代谢，预防或治疗脂肪肝和脂肪肝相关疾病。此外，本申请的戊二烯酰化合物可能增加细胞中SIRT1的表达水平或SIRT1的活性，因此可用于预防或治疗SIRT1介导的疾病。此外，本申请的戊二烯酰化合物可能降低细胞中CK2的表达水平或CK2的活性，因此可用于预防或治疗CK2介导的疾病。
• 2-PROPYNYL ADENOSINE ANALOGS HAVING A2A AGONIST ACTIVITY AND COMPOSITIONS THEREOF
  申请人：Linden M. Joel

  公开号：US20070232559A1

  公开（公告）日：2007-10-04

  The invention provides compounds having the following general formula (I): wherein X, R 1 , R 2 , R 7 and Z are as described here.

  该发明提供具有以下一般式（I）的化合物：其中X，R1，R2，R7和Z如此描述。
• 2-PROPYNYL ADENOSINE ANALOGS WITH MODIFIED 5'-RIBOSE GROUPS HAVING A2A AGONIST ACTIVITY
  申请人：Rieger Jayson M.

  公开号：US20090253647A1

  公开（公告）日：2009-10-08

  The invention provides compounds having the following general formula (I): wherein X, R 1 , R 2 , R 7 and Z are as described herein.

  本发明提供具有以下一般式（I）的化合物：其中X，R1，R2，R7和Z如本文所述。
• N-SULFONYLUREA APOPTOSIS PROMOTERS
  申请人：Elmore Steven W.

  公开号：US20080146572A1

  公开（公告）日：2008-06-19

  Compounds having the formula are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

  具有以下化学式的化合物是凋亡促进剂。还公开了制备这些化合物的方法，含有这些化合物的组合物以及使用这些化合物进行治疗的方法。
• 2-POLYCYCLIC PROPYNYL ADENOSINE ANALOGS HAVING A2A AGONIST ACTIVITY
  申请人：Rieger Jayson M.

  公开号：US20090298788A1

  公开（公告）日：2009-12-03

  The invention provides compounds having the following general formula (I): wherein X, R 1 , R 2 , R 7 and Z are as described herein.

  本发明提供具有以下一般式(I)的化合物：其中X、R1、R2、R7和Z如本文所述。