4-(3-methyl-4-m-tolyl-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl-6'-yl)-benzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-(3-methyl-4-m-tolyl-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl-6'-yl)-benzamide
• 英文别名: 4-[6-[3-Methyl-4-(m-tolyl)piperazin-1-yl]pyrazin-2-yl]benzamide；4-[6-[3-methyl-4-(3-methylphenyl)piperazin-1-yl]pyrazin-2-yl]benzamide
• 化学式: C₂₃H₂₅N₅O
• 分子量: 387.484
• InChiKey: HQYNHFNPHXMVGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  75.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Pyrazine Derivatives As Effective Compounds Against Infectious Diseases
  申请人：Eikhoff Jan Eike

  公开号：US20080194574A1

  公开（公告）日：2008-08-14

  The present invention relates to pyrazine derivatives according to the general formula (I) and pharmaceutically acceptable salts thereof and their use as pharmaceutical compounds as well as the use of these compounds for the preparation of a pharmaceutical composition for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases, stroke and especially for the treatment of herpesviral induced infections, including opportunistic infections as well as infections and diseases caused by human cytomegalovirus (HCMV).