(R)-2-[((R)-2-Hydroxy-1-methyl-ethyl)-dimethyl-silanyl]-propan-1-ol | 85337-68-4

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (R)-2-[((R)-2-Hydroxy-1-methyl-ethyl)-dimethyl-silanyl]-propan-1-ol
• 英文别名: (2R)-2-[[(2R)-1-hydroxypropan-2-yl]-dimethylsilyl]propan-1-ol
• CAS: 85337-68-4
• 化学式: C₈H₂₀O₂Si
• 分子量: 176.331
• InChiKey: VOGFUHMPCHHSIJ-HTQZYQBOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.46
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  二-(2-丙烯基)二甲基硅烷 在 chloro(1,5-cyclooctadiene)rhodium(I) dimer 、 (S)-(+)-2-异丙基-5-甲基二苯磷 sodium hydroxide 、 双氧水 、 儿萘酚硼烷 作用下， 生成 (R)-2-[((S)-2-Hydroxy-1-methyl-ethyl)-dimethyl-silanyl]-propan-1-ol 、 (R)-2-[((R)-2-Hydroxy-1-methyl-ethyl)-dimethyl-silanyl]-propan-1-ol
  参考文献：
  名称：

  Ligand controlled diastereoselectivity in the rhodium catalysed hydroboration of divinylsilanes

  摘要：

  The diastereoselectivity of the rhodium catalysed hydroboration of divinylsilanes is found to vary according to the length of the tether between the two phosphine ligands. Maximum diastereoselectivity is observed for butanodiphosphines and this may be related to the stability of a cis divinylsilane-diphosphine rhodium complex.

  DOI：

  10.1016/s0040-4039(00)76235-6

文献信息

• Direct synthesis of metallacycloalkanones via the cyclic hydroboration of dialkenyl derivatives of silicon, germanium and tin
  作者：John A. Soderquist、Alfred Hassner

  DOI：10.1021/jo00159a003

  日期：1983.6
• Ligand controlled diastereoselectivity in the rhodium catalysed hydroboration of divinylsilanes
  作者：Jennifer L. Matthews、Patrick G. Steel

  DOI：10.1016/s0040-4039(00)76235-6

  日期：1994.2

  The diastereoselectivity of the rhodium catalysed hydroboration of divinylsilanes is found to vary according to the length of the tether between the two phosphine ligands. Maximum diastereoselectivity is observed for butanodiphosphines and this may be related to the stability of a cis divinylsilane-diphosphine rhodium complex.