3-sec-Butyl-benzofuran | 105230-34-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 3-sec-Butyl-benzofuran
• 英文别名: 3-Butan-2-yl-1-benzofuran
• CAS: 105230-34-0
• 化学式: C₁₂H₁₄O
• 分子量: 174.243
• InChiKey: AHXJZMFULGGFPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  13.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (2,2,2-trifluoroethoxy)benzene 、 仲丁基锂 以40%的产率得到3-sec-Butyl-benzofuran
  参考文献：
  名称：

  Halocarbon chemistry. 3. Ortho metallation-induced cyclization of acetylenes: one-flask synthesis of 2,3-disubstituted benzofurans, thianaphthenes and indoles

  摘要：

  DOI：

  10.1021/jo00375a063

文献信息

• Dihydropyrancarboxamides and uses thereof
  申请人：Schreiber L. Stuart

  公开号：US20080070916A1

  公开（公告）日：2008-03-20

  The present invention provides novel dihydropyrancarboxamide compounds of formula (I): and collections of these compounds, and provides methods for the synthesis of these compounds; wherein R 1 -R 6 are as defined herein. Additionally, the present invention provides pharmaceutical compositions and methods for treating disorders such as proliferative diseases, and cancer, to name a few.

  本发明提供了式（I）的新型二氢吡嗪羧酰胺化合物以及这些化合物的集合，并提供了合成这些化合物的方法；其中R1-R6如本文所定义。此外，本发明还提供了治疗增生性疾病和癌症等疾病的药物组合物和方法。
• DIHYDROPTERIDINONE DERIVATIVES AND USES THEREOF
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US20170145013A1

  公开（公告）日：2017-05-25

  The present disclosure provides compounds of Formula (I), and pharmaceutically compositions thereof. Compounds of Formula (I) have been found to bind bromodomains and/or bromodomain-containing proteins (e.g., bromo and extra terminal (BET) proteins). Also provided are methods, uses, and kits of the compounds and pharmaceutical compositions for inhibiting the activity (e.g., increased activity) of bromodomains and/or bromodomain-containing proteins and for treating and/or preventing in a subject diseases associated with bromodomains or bromodomain-containing proteins (e.g., proliferative diseases, cardiovascular diseases, viral infections, fibrotic diseases, neurological diseases, metabolic diseases, endocrine diseases, and radiation poisoning). The compounds, pharmaceutical compositions, and kits are also useful for male contraception.
• US9951074B2
  申请人：——

  公开号：US9951074B2

  公开（公告）日：2018-04-24
• Halocarbon chemistry. 3. Ortho metallation-induced cyclization of acetylenes: one-flask synthesis of 2,3-disubstituted benzofurans, thianaphthenes and indoles
  作者：Francis Johnson、Raghupathi Subramanian

  DOI：10.1021/jo00375a063

  日期：1986.12