3,5-dimethyl-1-(α-D-arabinofuranosyl)pyrazole | 55726-18-6

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 吡唑核糖核苷和核糖核苷酸
• 英文名称: 3,5-dimethyl-1-(α-D-arabinofuranosyl)pyrazole
• 英文别名: 3,5-dimethyl-1-(alpha-D-arabinofuranosyl)pyrazole；(2S,3S,4S,5R)-2-(3,5-dimethylpyrazol-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol
• CAS: 55726-18-6
• 化学式: C₁₀H₁₆N₂O₄
• 分子量: 228.248
• InChiKey: NRGGBAJCPZXJIK-IMSYWVGJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  87.7
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3,5-dimethyl-1-(2,3,5-tri-O-benzyl-α-D-arabinofuranosyl)pyrazole 在 钯 甲醇 作用下， 以 甲醇 、 盐酸 为溶剂， 反应 22.0h， 生成 3,5-dimethyl-1-(α-D-arabinofuranosyl)pyrazole
  参考文献：
  名称：

  Derivatives of hydrazino-monosaccharides and aldohexoses which are

  摘要：

  提供了替代的肼基和吡唑醛糖和醛己糖，这些化合物可用作制备化合物的中间体，降低血液中尿酸水平的化合物和杀菌剂。替代的肼基化合物还可以进行其未取代对应物无法进行的化学反应。

  公开号：

  US04021542A1

文献信息

• Derivatives of hydrazino-monosaccharides and aldohexoses which are
  申请人：Byk Gulden Lomberg Chemische Fabrik GmbH

  公开号：US04021542A1

  公开（公告）日：1977-05-03

  Substituted hydrazino- and pyrazolo-aldopentoses and aldohexoses, which are useful as intermediates for preparing compounds, as compounds which lower the uric acid level in the blood, and as bactericides, are provided. The substituted hydrazino compounds also enter into chemical reactions which are not possible with their unsubstituted counterparts.

  提供了替代的肼基和吡唑醛糖和醛己糖，这些化合物可用作制备化合物的中间体，降低血液中尿酸水平的化合物和杀菌剂。替代的肼基化合物还可以进行其未取代对应物无法进行的化学反应。
• Heterocyclic derivatives of sugars: an NMR study of the formation of 1-glycosyl-3,5-dimethyl-1 H-pyrazoles from hydrazones
  作者：Warren C Kett、Michael Batley、John W Redmond

  DOI：10.1016/s0008-6215(97)00007-4

  日期：1997.4

  Hydrazones were prepared by treatment of monosaccharides and disaccharides with hydrazine hydrate and converted in high yield to mixtures of 1-glycosyl-3,5-dimethyl-1 H-pyrazoles by reaction with pentan-2,4-dione (acetylacetone). The isomeric products were separated by HPLC and characterized by NMR spectroscopy. This represents a new approach to the introduction of a heteroaromatic label into sugars under nonacidic and nonreducing conditions, and it is a process likely to be especially useful for glycan hydrazones obtained from glycoproteins by hydrazinolysis or beta elimination in the presence of hydrazine. (C) 1997 Elsevier Science Ltd.
• US4021542A
  申请人：——

  公开号：US4021542A

  公开（公告）日：1977-05-03
• Schmidt; Guilliard; Heermann, Journal of Heterocyclic Chemistry, 1983, vol. 20, # 6, p. 1447 - 1451
  作者：Schmidt、Guilliard、Heermann、Hoffmann

  DOI：——

  日期：——