1-[3-(Furan-2-yl)pyridin-2-yl]piperazine | 1256835-51-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-[3-(Furan-2-yl)pyridin-2-yl]piperazine
• CAS: 1256835-51-4
• 化学式: C₁₃H₁₅N₃O
• 分子量: 229.28
• InChiKey: BTZGJFNJWNHYJA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  41.3
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Substituted benzazoles and methods of their use as inhibitors of Raf kinase
  申请人：——

  公开号：US20040122237A1

  公开（公告）日：2004-06-24

  New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.

  提供了新的替代苯唑化合物、组合物和抑制人类或动物主体中Raf激酶活性的方法。这些新化合物组合物可以单独使用，也可以与至少一种额外药物结合，用于治疗由Raf激酶介导的疾病，如癌症。
• [EN] COMPOUNDS USEFUL FOR TREATING A MANNHEIMIA HAEMOLYTICA OR HISTOPHILUS SOMNI INFECTION<br/>[FR] COMPOSÉS UTILES POUR TRAITER UNE INFECTION PAR MANNHEIMIA HAEMOLYTICA OU HISTOPHILUS SOMNI
  申请人：INTERVET INT BV

  公开号：WO2018115421A1

  公开（公告）日：2018-06-28

  The present invention discloses compounds of formula (I) that are useful in the treatment of respiratory diseases of animals, especially Bovine or Swine Respiratory disease (BRD and SRD).

  本发明公开了一种化合物，其化学式为（I），可用于治疗动物的呼吸道疾病，特别是牛或猪的呼吸道疾病（BRD和SRD）。
• 2,6-Disubstituted quinazolines, quinoxalines, quinolines and isoquinolines and methods of their use as inhibitors of RAF kinase
  申请人：Ramurthy Savithri

  公开号：US20050085482A1

  公开（公告）日：2005-04-21

  New substituted quinazoline, quinoxaline, quinoline and isoquinoline compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.

  提供了新的替代喹唑啉、喹喔啉、喹啉和异喹啉化合物、组合物以及在人类或动物主体中抑制Raf激酶活性的方法。这些新化合物组合物可以单独使用，也可以与至少一种额外药物联合使用，用于治疗由Raf激酶介导的疾病，如癌症。
• [EN] COMPOUNDS USEFUL FOR THE TREATMENT OF INFECTION WITH MANNHEIMIA HAEMOLYTICA OR HISTOPHILUS SOMNI<br/>[FR] COMPOSÉS UTILES POUR LE TRAITEMENT D'UNE INFECTION PAR MANNHEIMIA HAEMOLYTICA OU HISTOPHILUS SOMNI
  申请人：INTERVET INT BV

  公开号：WO2020002234A1

  公开（公告）日：2020-01-02

  The present invention discloses compounds that are useful in the treatment of respiratory diseases of animals, especially Bovine or Swine Respiratory disease (BRD and SRD)

  本发明公开了一种在治疗动物呼吸道疾病，特别是牛或猪呼吸道疾病（BRD和SRD）方面有用的化合物。
• [EN] PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3<br/>[FR] INHIBITEURS DE LA GLYCOGENE SYNTHASE KINASE 3 A BASE DE PYRROLE
  申请人：CHIRON CORP

  公开号：WO2004018455A1

  公开（公告）日：2004-03-04

  New pyrrole based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.

  提供了基于新吡咯烷基化合物的方法、组合物以及抑制体外糖原合成酶激酶（GSK3）活性和治疗体内GSK3介导的疾病的方法。该发明的方法、化合物和组合物可单独使用，也可与其他药理活性剂结合在一起，用于治疗由GSK3活性介导的疾病，如糖尿病、阿尔茨海默病和其他神经退行性疾病、肥胖、动脉粥样硬化心血管疾病、原发性高血压、多囊卵巢综合征、X综合征、缺血、创伤性脑损伤、躁狂抑郁症、免疫功能缺陷或癌症。