N-<2-Ethoxy-ethyl>-piperidin | 28665-98-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-<2-Ethoxy-ethyl>-piperidin
• 英文别名: N-(β-Ethoxyethyl)piperidin；1-(2-ethoxy-ethyl)-piperidine；1-(2-Aethoxy-aethyl)-piperidin；1-(2-Ethoxyethyl)piperidine
• CAS: 28665-98-7
• 化学式: C₉H₁₉NO
• mdl: MFCD30293158
• 分子量: 157.256
• InChiKey: FMYGTNODXBDYRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  sodium ethanolate 、 alkaline earth salt of/the/ methylsulfuric acid 生成 N-<2-Ethoxy-ethyl>-piperidin
  参考文献：
  名称：

  Knorr; Hoerlein; Roth, Chemische Berichte, 1905, vol. 38, p. 3138

  摘要：

  DOI：

文献信息

• [EN] BIARYLTRIAZOLE INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR<br/>[FR] INHIBITEURS DE TRIAZOLE BIARYLE DU FACTEUR INHIBITEUR DE LA MIGRATION DES MACROPHAGES
  申请人：UNIV YALE

  公开号：WO2016130968A1

  公开（公告）日：2016-08-18

  The present disclosure describes biaryl triazole compounds, as well as their compositions and methods of use. The compounds inhibit the activity of macrophage migration inhibitory factor and are useful for the treatment of diseases, e.g., inflammatory diseases and cancer.

  本公开描述了联苯三唑化合物，以及它们的组合物和使用方法。这些化合物抑制巨噬细胞迁移抑制因子的活性，并且对于治疗疾病，例如炎症性疾病和癌症，具有用处。
• NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
  申请人：BERNHART Claude

  公开号：US20100222319A1

  公开（公告）日：2010-09-02

  The disclosure relates to compounds of formula (I): wherein A, Z, Z′, L, R 2 and R 3 are as defined in the disclosure, to compositions comprising said compounds, and to methods for the manufacture and therapeutic use thereof.

  该公开涉及到式(I)的化合物： 其中A、Z、Z'、L、R2和R3如公开所定义，以及包含该化合物的组合物，以及用于其制备和治疗用途的方法。
• SUBSTITUTED 1-H-INDOL-3-YL-BENZAMIDE AND 1, 1'-BIPHENYL ANALOGS AS HISTONE DEMETHYLASE INHIBITORS
  申请人：University of Utah Research Foundation

  公开号：US20170283397A1

  公开（公告）日：2017-10-05

  Substituted 1-H-indol-3-yl-benzamide and 1, 1′-biphenyl analogs derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the LSD1.

  1-甲基吲哚-3-基苯甲酰胺和1,1'-联苯类似物衍生物，以及相关化合物，这些化合物可用作赖氨酸特异性组蛋白去甲基酶，包括LSD1的抑制剂；制备这些化合物的合成方法；包括这些化合物的药物组合物；以及使用这些化合物和组合物治疗与LSD1功能障碍相关的疾病的方法。
• BICYCLOHETEROARYL COMPOUNDS AND THEIR USE AS TRPV1 LIGANDS
  申请人：TAFESSE LAYKEA

  公开号：US20100130499A1

  公开（公告）日：2010-05-27

  The invention relates to compounds of formula I and pharmaceutically acceptable derivatives thereof, compositions comprising an effective amount of a compound of formula I or a pharmaceutically acceptable derivative thereof, and methods for treating or preventing a condition such as pain, UI, an ulcer, IBD and IBS, comprising administering to an animal in need thereof an effective amount of a compound of formula I or a pharmaceutically acceptable derivative thereof.

  该发明涉及公式I的化合物及其药用可接受的衍生物，包含有效量的公式I化合物或其药用可接受的衍生物的组合物，以及治疗或预防疼痛、尿失禁、溃疡、炎症性肠病和肠易激综合征等疾病的方法，包括向需要治疗的动物施用公式I化合物或其药用可接受的衍生物的有效量。
• AMINO PYRIMIDINE COMPOUND FOR INHIBITING PROTEIN TYROSINE KINASE ACTIVITY
  申请人：Shenzhen TargetRx, Inc.

  公开号：US20190152954A1

  公开（公告）日：2019-05-23

  An amino pyrimidine compound for inhibiting protein tyrosine kinase activity, a pharmaceutical composition thereof, preparation therefor, and an application thereof. Specifically, an amino pyrimidine compound represented by formula (I), R1, R2, L, Y, R6, W, A, m, and n being defined in the specification, and a pharmaceutically acceptable salt, a stereoisomer, a solvent compound, a hydrate, a polymorphism, a prodrug, or an isotope variant thereof. The compound can be used for treating and/or preventing protein tyrosine kinase-related diseases such as cell proliferative diseases, cancers, and immune diseases.

  一种用于抑制蛋白酪氨酸激酶活性的氨基嘧啶化合物，其制药组合物、制备方法及应用。具体来说，一种由式（I）表示的氨基嘧啶化合物，其中规范中定义了R1、R2、L、Y、R6、W、A、m和n，以及其药用可接受的盐、立体异构体、溶剂化合物、水合物、多形性、前药或同位素变体。该化合物可用于治疗和/或预防蛋白酪氨酸激酶相关疾病，如细胞增殖性疾病、癌症和免疫性疾病。